Synaptic Loss in Multiple Sclerosis Spinal Cord

Natalia Petrova; Erik Nutma; Daniele Carassiti; James Rs Newman; Sandra Amor; Daniel R Altmann; David Baker; Klaus Schmierer

doi:https://doi.org/10.1002/ana.25835

Synaptic Loss in Multiple Sclerosis Spinal Cord

Natalia Petrova, Erik Nutma, Daniele Carassiti, James Rs Newman, Sandra Amor, Daniel R Altmann, David Baker, Klaus Schmierer

Research output: Contribution to journal › Article › Academic › peer-review

17 Citations (Scopus)

Abstract

Disability in multiple sclerosis (MS) is considered primarily a result of axonal loss. However, correlation with spinal cord cross-sectional area—a predictor of disability—is poor, questioning the unique role of axonal loss. We investigated the degree of synaptic loss in postmortem spinal cords (18 chronic MS, 8 healthy controls) using immunohistochemistry for synaptophysin and synapsin. Substantial (58–96%) loss of synapses throughout the spinal cord was detected, along with moderate (47%) loss of anterior horn neurons, notably in demyelinating MS lesions. We conclude that synaptic loss is significant in chronic MS, likely contributing to disability accrual. ANN NEUROL 2020;88:619–625.

Original language	English
Pages (from-to)	619-625
Number of pages	7
Journal	Annals of neurology
Volume	88
Issue number	3
Early online date	30 Jun 2020
DOIs	https://doi.org/10.1002/ana.25835
Publication status	Published - 1 Sept 2020

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title = "Synaptic Loss in Multiple Sclerosis Spinal Cord",

abstract = "Disability in multiple sclerosis (MS) is considered primarily a result of axonal loss. However, correlation with spinal cord cross-sectional area—a predictor of disability—is poor, questioning the unique role of axonal loss. We investigated the degree of synaptic loss in postmortem spinal cords (18 chronic MS, 8 healthy controls) using immunohistochemistry for synaptophysin and synapsin. Substantial (58–96%) loss of synapses throughout the spinal cord was detected, along with moderate (47%) loss of anterior horn neurons, notably in demyelinating MS lesions. We conclude that synaptic loss is significant in chronic MS, likely contributing to disability accrual. ANN NEUROL 2020;88:619–625.",

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AU - Petrova, Natalia

AU - Nutma, Erik

AU - Carassiti, Daniele

AU - Rs Newman, James

AU - Amor, Sandra

AU - Altmann, Daniel R

AU - Baker, David

AU - Schmierer, Klaus

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N2 - Disability in multiple sclerosis (MS) is considered primarily a result of axonal loss. However, correlation with spinal cord cross-sectional area—a predictor of disability—is poor, questioning the unique role of axonal loss. We investigated the degree of synaptic loss in postmortem spinal cords (18 chronic MS, 8 healthy controls) using immunohistochemistry for synaptophysin and synapsin. Substantial (58–96%) loss of synapses throughout the spinal cord was detected, along with moderate (47%) loss of anterior horn neurons, notably in demyelinating MS lesions. We conclude that synaptic loss is significant in chronic MS, likely contributing to disability accrual. ANN NEUROL 2020;88:619–625.

AB - Disability in multiple sclerosis (MS) is considered primarily a result of axonal loss. However, correlation with spinal cord cross-sectional area—a predictor of disability—is poor, questioning the unique role of axonal loss. We investigated the degree of synaptic loss in postmortem spinal cords (18 chronic MS, 8 healthy controls) using immunohistochemistry for synaptophysin and synapsin. Substantial (58–96%) loss of synapses throughout the spinal cord was detected, along with moderate (47%) loss of anterior horn neurons, notably in demyelinating MS lesions. We conclude that synaptic loss is significant in chronic MS, likely contributing to disability accrual. ANN NEUROL 2020;88:619–625.

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Synaptic Loss in Multiple Sclerosis Spinal Cord

Abstract

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