TY - JOUR
T1 - Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis
AU - Kluza, Ewelina
AU - van der Schaft, Daisy W. J.
AU - Hautvast, Petra A. I.
AU - Mulder, Willem J. M.
AU - Mayo, Kevin H.
AU - Griffioen, Arjan W.
AU - Strijkers, Gustav J.
AU - Nicolay, Klaas
PY - 2010
Y1 - 2010
N2 - Effective and specific targeting of nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an alpha(v)beta(3) integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting
AB - Effective and specific targeting of nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an alpha(v)beta(3) integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting
U2 - https://doi.org/10.1021/nl902659g
DO - https://doi.org/10.1021/nl902659g
M3 - Article
C2 - 19968235
SN - 1530-6984
VL - 10
SP - 52
EP - 58
JO - Nano letters
JF - Nano letters
IS - 1
ER -