@article{dde076b7b51b4a68b087f0033aac5bb4,
title = "Synthesis and characterization of high affinity fluorogenic α-synuclein probes",
abstract = "Fluorescent small molecules are powerful tools for imaging α-synuclein pathology in vitro and in vivo. In this work, we explore benzofuranone as a potential scaffold for the design of fluorescent α-synuclein probes. These compounds have high affinity for α-synuclein, show fluorescent turn-on upon binding to fibrils, and display different binding to Lewy bodies, Lewy neurites and glial cytoplasmic inclusion pathologies in post-mortem brain tissue. These studies not only reveal the potential of benzofuranone compounds as α-synuclein specific fluorescent probes, but also have implications for the ways in which α-synucleinopathies are conformationally different and display distinct small molecule binding sites.",
author = "Zsofia Lengyel-Zhand and Ferrie, {John J.} and Bieneke Janssen and Hsieh, {Chia Ju} and Thomas Graham and Xu, {Kui Ying} and Haney, {Conor M.} and Lee, {Virginia M.Y.} and Trojanowski, {John Q.} and Petersson, {E. James} and Mach, {Robert H.}",
note = "Funding Information: This research was supported by the National Institutes of Health (NIH NS103873 to EJP and AG10124 and AG062418 to JQT and VMYL) and the Michael J. Fox Foundation (to RHM). Instruments supported by the NIH and National Science Foundation include NMR (NSF CHE-1827457) and mass spectrometers (NIH RR-023444 and NSF MRI-0820996). JJF thanks the NSF (DGE-1321851) and the Parkinson{\textquoteright}s Disease Foundation (PF-RVSA-SFW-1754) for fellowship support. CMH was supported by an Age-Related Neurodegenerative Disease Training Grant fellowship (NIH T32AG000255). Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry.",
year = "2020",
month = mar,
day = "25",
doi = "https://doi.org/10.1039/c9cc09849f",
language = "English",
volume = "56",
pages = "3567--3570",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "24",
}