System identification to analyse changed kinetics of SERCA in intact rat heart

Natal A.W. Van Riel; Tamas Ivanics; Laszlo Ligeti; Ger J. Van Der Vusse

doi:https://doi.org/10.1016/S1474-6670(17)33486-9

System identification to analyse changed kinetics of SERCA in intact rat heart

Natal A.W. Van Riel, Tamas Ivanics, Laszlo Ligeti, Ger J. Van Der Vusse

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

3 Citations (Scopus)

Abstract

A mechanistic-based model has been derived of calcium handling in the intact heart. This model incorporates the quantitatively most important processes involved in beat-to-beat calcium homeostasis. Based on a priori physiological information the model has been reduced to yield (kinetic) parameters that could be estimated using time-series data of the free calcium concentration in the sarcoplasma. Observations of the dynamics of the overall system were translated into the underlying mechanisms. Experiments in which the most important calcium extrusion pump (Sarcoplasmic Reticulum Ca²⁺-ATPase, SERCA) was disturbed have been successfully analysed and interpreted using model and identification.

Original language	English
Title of host publication	5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003
Pages	125-128
Number of pages	4
Volume	36
Edition	15
DOIs	https://doi.org/10.1016/S1474-6670(17)33486-9
Publication status	Published - 2003
Event	5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003 - Melbourne, Australia Duration: 21 Aug 2003 → 23 Aug 2003

Publication series

Name	IFAC Proceedings Volumes (IFAC-PapersOnline)

Conference

Conference	5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003
Country/Territory	Australia
City	Melbourne
Period	21/08/2003 → 23/08/2003

Keywords

Dynamic models
Identifiability
Least-squares identification
Model reduction
Parameter estimation
Physiological models

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https://doi.org/10.1016/S1474-6670(17)33486-9

Cite this

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title = "System identification to analyse changed kinetics of SERCA in intact rat heart",

abstract = "A mechanistic-based model has been derived of calcium handling in the intact heart. This model incorporates the quantitatively most important processes involved in beat-to-beat calcium homeostasis. Based on a priori physiological information the model has been reduced to yield (kinetic) parameters that could be estimated using time-series data of the free calcium concentration in the sarcoplasma. Observations of the dynamics of the overall system were translated into the underlying mechanisms. Experiments in which the most important calcium extrusion pump (Sarcoplasmic Reticulum Ca2+-ATPase, SERCA) was disturbed have been successfully analysed and interpreted using model and identification.",

keywords = "Dynamic models, Identifiability, Least-squares identification, Model reduction, Parameter estimation, Physiological models",

author = "{Van Riel}, {Natal A.W.} and Tamas Ivanics and Laszlo Ligeti and {Van Der Vusse}, {Ger J.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2003 IF AC.; 5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003 ; Conference date: 21-08-2003 Through 23-08-2003",

year = "2003",

doi = "https://doi.org/10.1016/S1474-6670(17)33486-9",

language = "English",

volume = "36",

series = "IFAC Proceedings Volumes (IFAC-PapersOnline)",

pages = "125--128",

booktitle = "5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003",

edition = "15",

}

Van Riel, NAW, Ivanics, T, Ligeti, L & Van Der Vusse, GJ 2003, System identification to analyse changed kinetics of SERCA in intact rat heart. in 5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003. 15 edn, vol. 36, IFAC Proceedings Volumes (IFAC-PapersOnline), pp. 125-128, 5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003, Melbourne, Australia, 21/08/2003. https://doi.org/10.1016/S1474-6670(17)33486-9

System identification to analyse changed kinetics of SERCA in intact rat heart. / Van Riel, Natal A.W.; Ivanics, Tamas; Ligeti, Laszlo et al.
5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003. Vol. 36 15. ed. 2003. p. 125-128 (IFAC Proceedings Volumes (IFAC-PapersOnline)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - System identification to analyse changed kinetics of SERCA in intact rat heart

AU - Van Riel, Natal A.W.

AU - Ivanics, Tamas

AU - Ligeti, Laszlo

AU - Van Der Vusse, Ger J.

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Y1 - 2003

N2 - A mechanistic-based model has been derived of calcium handling in the intact heart. This model incorporates the quantitatively most important processes involved in beat-to-beat calcium homeostasis. Based on a priori physiological information the model has been reduced to yield (kinetic) parameters that could be estimated using time-series data of the free calcium concentration in the sarcoplasma. Observations of the dynamics of the overall system were translated into the underlying mechanisms. Experiments in which the most important calcium extrusion pump (Sarcoplasmic Reticulum Ca2+-ATPase, SERCA) was disturbed have been successfully analysed and interpreted using model and identification.

AB - A mechanistic-based model has been derived of calcium handling in the intact heart. This model incorporates the quantitatively most important processes involved in beat-to-beat calcium homeostasis. Based on a priori physiological information the model has been reduced to yield (kinetic) parameters that could be estimated using time-series data of the free calcium concentration in the sarcoplasma. Observations of the dynamics of the overall system were translated into the underlying mechanisms. Experiments in which the most important calcium extrusion pump (Sarcoplasmic Reticulum Ca2+-ATPase, SERCA) was disturbed have been successfully analysed and interpreted using model and identification.

KW - Dynamic models

KW - Identifiability

KW - Least-squares identification

KW - Model reduction

KW - Parameter estimation

KW - Physiological models

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DO - https://doi.org/10.1016/S1474-6670(17)33486-9

M3 - Conference contribution

VL - 36

T3 - IFAC Proceedings Volumes (IFAC-PapersOnline)

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BT - 5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003

T2 - 5th IFAC Symposium on Modelling and Control in Biomedical Systems 2003

Y2 - 21 August 2003 through 23 August 2003

ER -

System identification to analyse changed kinetics of SERCA in intact rat heart

Abstract

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Conference

Keywords

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