Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

K. Reisinger; S. Hoffmann; N. Alépée; T. Ashikaga; J. Barroso; C. Elcombe; N. Gellatly; V. Galbiati; S. Gibbs; H. Groux; J. Hibatallah; D. Keller; P. Kern; M. Klaric; S. Kolle; J. Kuehnl; N. Lambrechts; M. Lindstedt; M. Millet; S. Martinozzi-Teissier; A. Natsch; D. Petersohn; I. Pike; H. Sakaguchi; A. Schepky; M. Tailhardat; M. Templier; E van Vliet; G. Maxwell

doi:https://doi.org/10.1016/j.tiv.2014.10.018

Systematic evaluation of non-animal test methods for skin sensitisation safety assessment

K. Reisinger, S. Hoffmann, N. Alépée, T. Ashikaga, J. Barroso, C. Elcombe, N. Gellatly, V. Galbiati, S. Gibbs, H. Groux, J. Hibatallah, D. Keller, P. Kern, M. Klaric, S. Kolle, J. Kuehnl, N. Lambrechts, M. Lindstedt, M. Millet, S. Martinozzi-TeissierA. Natsch, D. Petersohn, I. Pike, H. Sakaguchi, A. Schepky, M. Tailhardat, M. Templier, E van Vliet, G. Maxwell

Dermatology (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

112 Citations (Scopus)

Abstract

The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitisation potency prediction. The results of the first phase - systematic evaluation of 16 test methods - are presented here. This evaluation involved generation of data on a common set of ten substances in all methods and systematic collation of information including the level of standardisation, existing test data, potential for throughput, transferability and accessibility in cooperation with the test method developers. A workshop was held with the test method developers to review the outcome of this evaluation and to discuss the results. The evaluation informed the prioritisation of test methods for the next phase of the non-animal testing strategy development framework. Ultimately, the testing strategy - combined with bioavailability and skin metabolism data and exposure consideration - is envisaged to allow establishment of a data integration approach for skin sensitisation safety assessment of cosmetic ingredients.

Original language	English
Pages (from-to)	259-270
Journal	Toxicology in Vitro
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.tiv.2014.10.018
Publication status	Published - Feb 2015

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https://doi.org/10.1016/j.tiv.2014.10.018

Cite this

Reisinger, K., Hoffmann, S., Alépée, N., Ashikaga, T., Barroso, J., Elcombe, C., Gellatly, N., Galbiati, V., Gibbs, S., Groux, H., Hibatallah, J., Keller, D., Kern, P., Klaric, M., Kolle, S., Kuehnl, J., Lambrechts, N., Lindstedt, M., Millet, M., ... Maxwell, G. (2015). Systematic evaluation of non-animal test methods for skin sensitisation safety assessment. Toxicology in Vitro, 29(1), 259-270. https://doi.org/10.1016/j.tiv.2014.10.018

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title = "Systematic evaluation of non-animal test methods for skin sensitisation safety assessment",

abstract = "The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitisation potency prediction. The results of the first phase - systematic evaluation of 16 test methods - are presented here. This evaluation involved generation of data on a common set of ten substances in all methods and systematic collation of information including the level of standardisation, existing test data, potential for throughput, transferability and accessibility in cooperation with the test method developers. A workshop was held with the test method developers to review the outcome of this evaluation and to discuss the results. The evaluation informed the prioritisation of test methods for the next phase of the non-animal testing strategy development framework. Ultimately, the testing strategy - combined with bioavailability and skin metabolism data and exposure consideration - is envisaged to allow establishment of a data integration approach for skin sensitisation safety assessment of cosmetic ingredients.",

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Reisinger, K, Hoffmann, S, Alépée, N, Ashikaga, T, Barroso, J, Elcombe, C, Gellatly, N, Galbiati, V, Gibbs, S, Groux, H, Hibatallah, J, Keller, D, Kern, P, Klaric, M, Kolle, S, Kuehnl, J, Lambrechts, N, Lindstedt, M, Millet, M, Martinozzi-Teissier, S, Natsch, A, Petersohn, D, Pike, I, Sakaguchi, H, Schepky, A, Tailhardat, M, Templier, M, van Vliet, E & Maxwell, G 2015, 'Systematic evaluation of non-animal test methods for skin sensitisation safety assessment', Toxicology in Vitro, vol. 29, no. 1, pp. 259-270. https://doi.org/10.1016/j.tiv.2014.10.018

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AU - Reisinger, K.

AU - Hoffmann, S.

AU - Alépée, N.

AU - Ashikaga, T.

AU - Barroso, J.

AU - Elcombe, C.

AU - Gellatly, N.

AU - Galbiati, V.

AU - Gibbs, S.

AU - Groux, H.

AU - Hibatallah, J.

AU - Keller, D.

AU - Kern, P.

AU - Klaric, M.

AU - Kolle, S.

AU - Kuehnl, J.

AU - Lambrechts, N.

AU - Lindstedt, M.

AU - Millet, M.

AU - Martinozzi-Teissier, S.

AU - Natsch, A.

AU - Petersohn, D.

AU - Pike, I.

AU - Sakaguchi, H.

AU - Schepky, A.

AU - Tailhardat, M.

AU - Templier, M.

AU - van Vliet, E

AU - Maxwell, G.

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N2 - The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitisation potency prediction. The results of the first phase - systematic evaluation of 16 test methods - are presented here. This evaluation involved generation of data on a common set of ten substances in all methods and systematic collation of information including the level of standardisation, existing test data, potential for throughput, transferability and accessibility in cooperation with the test method developers. A workshop was held with the test method developers to review the outcome of this evaluation and to discuss the results. The evaluation informed the prioritisation of test methods for the next phase of the non-animal testing strategy development framework. Ultimately, the testing strategy - combined with bioavailability and skin metabolism data and exposure consideration - is envisaged to allow establishment of a data integration approach for skin sensitisation safety assessment of cosmetic ingredients.

AB - The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a solution, the Cosmetics Europe Skin Tolerance Task Force has defined a three-phase framework for the development of a non-animal testing strategy for skin sensitisation potency prediction. The results of the first phase - systematic evaluation of 16 test methods - are presented here. This evaluation involved generation of data on a common set of ten substances in all methods and systematic collation of information including the level of standardisation, existing test data, potential for throughput, transferability and accessibility in cooperation with the test method developers. A workshop was held with the test method developers to review the outcome of this evaluation and to discuss the results. The evaluation informed the prioritisation of test methods for the next phase of the non-animal testing strategy development framework. Ultimately, the testing strategy - combined with bioavailability and skin metabolism data and exposure consideration - is envisaged to allow establishment of a data integration approach for skin sensitisation safety assessment of cosmetic ingredients.

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DO - https://doi.org/10.1016/j.tiv.2014.10.018

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