TY - JOUR
T1 - Systematic Review of Polygenic Gene–Environment Interaction in Tobacco, Alcohol, and Cannabis Use
AU - Pasman, Joëlle A.
AU - Verweij, Karin J. H.
AU - Vink, Jacqueline M.
PY - 2019/7
Y1 - 2019/7
N2 - Studies testing the effect of single genetic variants on substance use have had modest success. This paper reviewed 39 studies using polygenic measures to test interaction with any type of environmental exposure (G×E) in alcohol, tobacco, and cannabis use. Studies using haplotype combinations, sum scores of candidate-gene risk alleles, and polygenic scores (PS) were included. Overall study quality was moderate, with lower ratings for the polygenic methods in the haplotype and candidate-gene score studies. Heterogeneity in investigated environmental exposures, genetic factors, and outcomes was substantial. Most studies (N = 30) reported at least one significant G×E interaction, but overall evidence was weak. The majority (N = 26) found results in line with differential susceptibility and diathesis-stress frameworks. Future studies should pay more attention to methodological and statistical rigor, and focus on replication efforts. Additional work is needed before firm conclusions can be drawn about the importance of G×E in the etiology of substance use.
AB - Studies testing the effect of single genetic variants on substance use have had modest success. This paper reviewed 39 studies using polygenic measures to test interaction with any type of environmental exposure (G×E) in alcohol, tobacco, and cannabis use. Studies using haplotype combinations, sum scores of candidate-gene risk alleles, and polygenic scores (PS) were included. Overall study quality was moderate, with lower ratings for the polygenic methods in the haplotype and candidate-gene score studies. Heterogeneity in investigated environmental exposures, genetic factors, and outcomes was substantial. Most studies (N = 30) reported at least one significant G×E interaction, but overall evidence was weak. The majority (N = 26) found results in line with differential susceptibility and diathesis-stress frameworks. Future studies should pay more attention to methodological and statistical rigor, and focus on replication efforts. Additional work is needed before firm conclusions can be drawn about the importance of G×E in the etiology of substance use.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066893700&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31111357
U2 - https://doi.org/10.1007/s10519-019-09958-7
DO - https://doi.org/10.1007/s10519-019-09958-7
M3 - Review article
C2 - 31111357
SN - 0001-8244
VL - 49
SP - 349
EP - 365
JO - Behavior genetics
JF - Behavior genetics
IS - 4
ER -