@article{77f654e8707b447e821b3b9bfd69ef65,
title = "Systematic review on sleeve gastrectomy or Roux-en-Y gastric bypass surgery for refractory gastroparesis",
abstract = "Management of refractory gastroparesis is challenging after diet, prokinetics, and long-term nutritional support have failed. In this review, the efficacy and safety of surgical interventions (sleeve gastrectomy and Roux-en-Y gastric bypass surgery) are evaluated systematically in patients with refractory gastroparesis. The PubMed, Embase, and Scopus databases were searched to identify relevant studies published up to June 2021. Outcome of interest was symptom improvement and gastric emptying. Nineteen studies with 222 refractory gastroparesis patients (147 Roux-en-Y gastric bypass, 39 sleeve gastrectomy, and 36 subtotal gastrectomy) were included. All studies reported symptom improvement postoperatively, particularly vomiting and nausea. Gastric emptying improved postoperatively in 45% up to 67% for sleeve gastrectomy and 87% for Roux-en-Y gastric bypass. The findings of our systematic review suggest that sleeve gastrectomy and Roux-en-Y gastric bypass surgery improve symptoms and gastric emptying in patients with refractory gastroparesis. Surgery may be effective as treatment for a small group of patients when all other therapies have failed.",
keywords = "Gastroparesis, Refractory gastroparesis, Roux-en-Y gastric bypass surgery, Sleeve gastrectomy",
author = "Masclee, {Gwen M. C.} and Daniel Keszthelyi and Conchillo, {Jos{\'e} M.} and Kruimel, {Joanna W.} and Bouvy, {Nicole D.} and Masclee, {Ad A. M.}",
note = "Funding Information: G.M.C. Masclee, J.W. Kruimel, N.D. Bouvy, and J.M. Conchillo have no conflicts of interest to report. A.A.M. Masclee has received a Netherlands Organization for Health Research and Development (ZonMw) health care efficiency grant to evaluate the efficacy of peppermint oil in irritable bowel syndrome; has received an unrestricted research grant from Will Pharma S.A.; has received a grant from the Dutch Cancer Society related to endoscopy and colorectal polyps; has received funding from Pentax Europe GmBH; has received research funding from Allegan and Gr{\"u}nenthal on irritable bowel syndrome topics; and has given scientific advice to Bayer (topic: irritable bowel syndrome), to Kyowa Kirin (topic: constipation), and to Takeda (topic: gastroparesis). D. Keszthelyi has received research funding for the establishment of irritable bowel syndrome centers of excellence in The Netherlands and has received research funding from Will Pharma , Allergan , Gr{\"u}nenthal , ZonMw , UEG, and the Rome Foundation outside of the submitted work. Publisher Copyright: {\textcopyright} 2022 American Society for Metabolic and Bariatric Surgery",
year = "2022",
doi = "https://doi.org/10.1016/j.soard.2022.09.009",
language = "English",
journal = "Surgery for Obesity and Related Diseases",
issn = "1550-7289",
publisher = "Elsevier Inc.",
}