Systems medicine and integrated care to combat chronic noncommunicable diseases

Jean Bousquet; Josep M. Anto; Peter J. Sterk; Ian M. Adcock; Kian Fan Chung; Josep Roca; Alvar Agusti; Chris Brightling; Anne Cambon-Thomsen; Alfredo Cesario; Sonia Abdelhak; Stylianos E. Antonarakis; Antoine Avignon; Andrea Ballabio; Eugenio Baraldi; Alexander Baranov; Thomas Bieber; Joël Bockaert; Samir Brahmachari; Christian Brambilla; Jacques Bringer; Michel Dauzat; Ingemar Ernberg; Leonardo Fabbri; Philippe Froguel; David Galas; Takashi Gojobori; Peter Hunter; Christian Jorgensen; Francine Kauffmann; Philippe Kourilsky; Marek L. Kowalski; Doron Lancet; Claude Le Pen; Jacques Mallet; Bongani Mayosi; Jacques Mercier; Andres Metspalu; Joseph H. Nadeau; Grégory Ninot; Denis Noble; Mehmet Oztürk; Susanna Palkonen; Christian Préfaut; Klaus Rabe; Eric Renard; Richard G. Roberts; Boleslav Samolinski; Holger J. Schünemann; Hans-Uwe Simon; Marcelo Bento Soares; Giulio Superti-Furga; Jesper Tegner; Sergio Verjovski-Almeida; Peter Wellstead; Olaf Wolkenhauer; Emiel Wouters; Rudi Balling; Anthony J. Brookes; Dominique Charron; Christophe Pison; Zhu Chen; Leroy Hood; Charles Auffray

doi:https://doi.org/10.1186/gm259

Systems medicine and integrated care to combat chronic noncommunicable diseases

Jean Bousquet, Josep M. Anto, Peter J. Sterk, Ian M. Adcock, Kian Fan Chung, Josep Roca, Alvar Agusti, Chris Brightling, Anne Cambon-Thomsen, Alfredo Cesario, Sonia Abdelhak, Stylianos E. Antonarakis, Antoine Avignon, Andrea Ballabio, Eugenio Baraldi, Alexander Baranov, Thomas Bieber, Joël Bockaert, Samir Brahmachari, Christian BrambillaJacques Bringer, Michel Dauzat, Ingemar Ernberg, Leonardo Fabbri, Philippe Froguel, David Galas, Takashi Gojobori, Peter Hunter, Christian Jorgensen, Francine Kauffmann, Philippe Kourilsky, Marek L. Kowalski, Doron Lancet, Claude Le Pen, Jacques Mallet, Bongani Mayosi, Jacques Mercier, Andres Metspalu, Joseph H. Nadeau, Grégory Ninot, Denis Noble, Mehmet Oztürk, Susanna Palkonen, Christian Préfaut, Klaus Rabe, Eric Renard, Richard G. Roberts, Boleslav Samolinski, Holger J. Schünemann, Hans-Uwe Simon, Marcelo Bento Soares, Giulio Superti-Furga, Jesper Tegner, Sergio Verjovski-Almeida, Peter Wellstead, Olaf Wolkenhauer, Emiel Wouters, Rudi Balling, Anthony J. Brookes, Dominique Charron, Christophe Pison, Zhu Chen, Leroy Hood, Charles Auffray

Research output: Contribution to journal › Article › Academic › peer-review

169 Citations (Scopus)

Abstract

ABSTRACT: We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems

Original language	English
Pages (from-to)	43
Journal	Genome Medicine
Volume	3
Issue number	7
DOIs	https://doi.org/10.1186/gm259
Publication status	Published - 2011

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https://doi.org/10.1186/gm259

Cite this

Bousquet, J., Anto, J. M., Sterk, P. J., Adcock, I. M., Chung, K. F., Roca, J., Agusti, A., Brightling, C., Cambon-Thomsen, A., Cesario, A., Abdelhak, S., Antonarakis, S. E., Avignon, A., Ballabio, A., Baraldi, E., Baranov, A., Bieber, T., Bockaert, J., Brahmachari, S., ... Auffray, C. (2011). Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Medicine, 3(7), 43. https://doi.org/10.1186/gm259

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abstract = "ABSTRACT: We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems",

author = "Jean Bousquet and Anto, {Josep M.} and Sterk, {Peter J.} and Adcock, {Ian M.} and Chung, {Kian Fan} and Josep Roca and Alvar Agusti and Chris Brightling and Anne Cambon-Thomsen and Alfredo Cesario and Sonia Abdelhak and Antonarakis, {Stylianos E.} and Antoine Avignon and Andrea Ballabio and Eugenio Baraldi and Alexander Baranov and Thomas Bieber and Jo{\"e}l Bockaert and Samir Brahmachari and Christian Brambilla and Jacques Bringer and Michel Dauzat and Ingemar Ernberg and Leonardo Fabbri and Philippe Froguel and David Galas and Takashi Gojobori and Peter Hunter and Christian Jorgensen and Francine Kauffmann and Philippe Kourilsky and Kowalski, {Marek L.} and Doron Lancet and Pen, {Claude Le} and Jacques Mallet and Bongani Mayosi and Jacques Mercier and Andres Metspalu and Nadeau, {Joseph H.} and Gr{\'e}gory Ninot and Denis Noble and Mehmet Ozt{\"u}rk and Susanna Palkonen and Christian Pr{\'e}faut and Klaus Rabe and Eric Renard and Roberts, {Richard G.} and Boleslav Samolinski and Sch{\"u}nemann, {Holger J.} and Hans-Uwe Simon and Soares, {Marcelo Bento} and Giulio Superti-Furga and Jesper Tegner and Sergio Verjovski-Almeida and Peter Wellstead and Olaf Wolkenhauer and Emiel Wouters and Rudi Balling and Brookes, {Anthony J.} and Dominique Charron and Christophe Pison and Zhu Chen and Leroy Hood and Charles Auffray",

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doi = "https://doi.org/10.1186/gm259",

language = "English",

volume = "3",

pages = "43",

journal = "Genome Medicine",

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Bousquet, J, Anto, JM, Sterk, PJ, Adcock, IM, Chung, KF, Roca, J, Agusti, A, Brightling, C, Cambon-Thomsen, A, Cesario, A, Abdelhak, S, Antonarakis, SE, Avignon, A, Ballabio, A, Baraldi, E, Baranov, A, Bieber, T, Bockaert, J, Brahmachari, S, Brambilla, C, Bringer, J, Dauzat, M, Ernberg, I, Fabbri, L, Froguel, P, Galas, D, Gojobori, T, Hunter, P, Jorgensen, C, Kauffmann, F, Kourilsky, P, Kowalski, ML, Lancet, D, Pen, CL, Mallet, J, Mayosi, B, Mercier, J, Metspalu, A, Nadeau, JH, Ninot, G, Noble, D, Oztürk, M, Palkonen, S, Préfaut, C, Rabe, K, Renard, E, Roberts, RG, Samolinski, B, Schünemann, HJ, Simon, H-U, Soares, MB, Superti-Furga, G, Tegner, J, Verjovski-Almeida, S, Wellstead, P, Wolkenhauer, O, Wouters, E, Balling, R, Brookes, AJ, Charron, D, Pison, C, Chen, Z, Hood, L & Auffray, C 2011, 'Systems medicine and integrated care to combat chronic noncommunicable diseases', Genome Medicine, vol. 3, no. 7, pp. 43. https://doi.org/10.1186/gm259

TY - JOUR

T1 - Systems medicine and integrated care to combat chronic noncommunicable diseases

AU - Bousquet, Jean

AU - Anto, Josep M.

AU - Sterk, Peter J.

AU - Adcock, Ian M.

AU - Chung, Kian Fan

AU - Roca, Josep

AU - Agusti, Alvar

AU - Brightling, Chris

AU - Cambon-Thomsen, Anne

AU - Cesario, Alfredo

AU - Abdelhak, Sonia

AU - Antonarakis, Stylianos E.

AU - Avignon, Antoine

AU - Ballabio, Andrea

AU - Baraldi, Eugenio

AU - Baranov, Alexander

AU - Bieber, Thomas

AU - Bockaert, Joël

AU - Brahmachari, Samir

AU - Brambilla, Christian

AU - Bringer, Jacques

AU - Dauzat, Michel

AU - Ernberg, Ingemar

AU - Fabbri, Leonardo

AU - Froguel, Philippe

AU - Galas, David

AU - Gojobori, Takashi

AU - Hunter, Peter

AU - Jorgensen, Christian

AU - Kauffmann, Francine

AU - Kourilsky, Philippe

AU - Kowalski, Marek L.

AU - Lancet, Doron

AU - Pen, Claude Le

AU - Mallet, Jacques

AU - Mayosi, Bongani

AU - Mercier, Jacques

AU - Metspalu, Andres

AU - Nadeau, Joseph H.

AU - Ninot, Grégory

AU - Noble, Denis

AU - Oztürk, Mehmet

AU - Palkonen, Susanna

AU - Préfaut, Christian

AU - Rabe, Klaus

AU - Renard, Eric

AU - Roberts, Richard G.

AU - Samolinski, Boleslav

AU - Schünemann, Holger J.

AU - Simon, Hans-Uwe

AU - Soares, Marcelo Bento

AU - Superti-Furga, Giulio

AU - Tegner, Jesper

AU - Verjovski-Almeida, Sergio

AU - Wellstead, Peter

AU - Wolkenhauer, Olaf

AU - Wouters, Emiel

AU - Balling, Rudi

AU - Brookes, Anthony J.

AU - Charron, Dominique

AU - Pison, Christophe

AU - Chen, Zhu

AU - Hood, Leroy

AU - Auffray, Charles

PY - 2011

Y1 - 2011

N2 - ABSTRACT: We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems

AB - ABSTRACT: We propose an innovative, integrated, cost-effective health system to combat major non-communicable diseases (NCDs), including cardiovascular, chronic respiratory, metabolic, rheumatologic and neurologic disorders and cancers, which together are the predominant health problem of the 21st century. This proposed holistic strategy involves comprehensive patient-centered integrated care and multi-scale, multi-modal and multi-level systems approaches to tackle NCDs as a common group of diseases. Rather than studying each disease individually, it will take into account their intertwined gene-environment, socio-economic interactions and co-morbidities that lead to individual-specific complex phenotypes. It will implement a road map for predictive, preventive, personalized and participatory (P4) medicine based on a robust and extensive knowledge management infrastructure that contains individual patient information. It will be supported by strategic partnerships involving all stakeholders, including general practitioners associated with patient-centered care. This systems medicine strategy, which will take a holistic approach to disease, is designed to allow the results to be used globally, taking into account the needs and specificities of local economies and health systems

U2 - https://doi.org/10.1186/gm259

DO - https://doi.org/10.1186/gm259

M3 - Article

C2 - 21745417

SN - 1756-994X

VL - 3

SP - 43

JO - Genome Medicine

JF - Genome Medicine

IS - 7

ER -