Abstract
T cell proliferative responses against human papillomavirus type 16 (HPV-16) E7 protein were studied in relation to HPV status over time in 51 women originally diagnosed with abnormal cervical cytology and participating in a follow-up study. HPV-16-positive patients were grouped as having either a persistent, a cleared or a fluctuating HPV-16 infection as determined by PCR in consecutive cervical smears up until the moment of testing. Positive proliferative responses against HPV-16 E7 were found in 15/26 patients with a persistent, cleared or fluctuating HPV-16 infection (57.7%). In contrast, 0/15 patients who had been typed HPV-negative during follow-up showed positive responses (P = 0.0005). Further analysis showed positive responses to be more frequent in patients with persistent HPV-16 infections and stable or progressing cervical lesions (8/9 patients reactive, 88.9%) as compared to patients with cleared or fluctuating HPV-16 infections and stable or regressing cervical lesions (7/17, 41.1%, P = 0.04). The relatively strong T cell proliferative responses against HPV-16 E7 observed in patients with a persistent HPV-16 infection and progressive cervical lesions indicate that the effectivity of such responses cannot be predicted and apparently depends on additional factors.
Original language | English |
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Pages (from-to) | 2183-91 |
Number of pages | 9 |
Journal | Journal of general virology |
Volume | 77 ( Pt 9) |
DOIs | |
Publication status | Published - Sept 1996 |
Keywords
- Adult
- Amino Acid Sequence
- Antigens, Viral/genetics
- Binding Sites
- Cell Division
- Cells, Cultured
- Cervical Intraepithelial Neoplasia/immunology
- Female
- Follow-Up Studies
- Humans
- Middle Aged
- Molecular Sequence Data
- Oncogene Proteins, Viral/chemical synthesis
- Papillomaviridae/genetics
- Papillomavirus E7 Proteins
- Papillomavirus Infections/immunology
- Recombinant Fusion Proteins/genetics
- T-Lymphocytes/immunology
- Tumor Virus Infections/immunology
- Uterine Cervical Neoplasms/immunology
- Virus Latency