TY - JOUR
T1 - T1/T2-weighted ratio
T2 - A feasible MRI biomarker in multiple sclerosis
AU - Boaventura, Mateus
AU - Sastre-Garriga, Jaume
AU - Rimkus, Carolina de Medeiros
AU - Rovira, Àlex
AU - Pareto, Deborah
N1 - Publisher Copyright: © The Author(s), 2024.
PY - 2024/3
Y1 - 2024/3
N2 - T1/T2-weighted ratio is a novel magnetic resonance imaging (MRI) biomarker based on conventional sequences, related to microstructural integrity and with increasing use in multiple sclerosis (MS) research. Different from other advanced MRI techniques, this method has the advantage of being based on routinely acquired MRI sequences, a feature that enables analysis of retrospective cohorts with considerable clinical value. This article provides an overview of this method, describing the previous cross-sectional and longitudinal findings in the main MS clinical phenotypes and in different brain tissues: focal white matter (WM) lesions, normal-appearing white matter (NAWM), cortical gray matter (GM), and deep normal-appearing gray matter (NAGM). We also discuss the clinical associations, possible reasons for conflicting results, correlations with other MRI-based measures, and histopathological associations. We highlight the limitations of the biomarker itself and the methodology of each study. Finally, we update the reader on its potential use as an imaging biomarker in research.
AB - T1/T2-weighted ratio is a novel magnetic resonance imaging (MRI) biomarker based on conventional sequences, related to microstructural integrity and with increasing use in multiple sclerosis (MS) research. Different from other advanced MRI techniques, this method has the advantage of being based on routinely acquired MRI sequences, a feature that enables analysis of retrospective cohorts with considerable clinical value. This article provides an overview of this method, describing the previous cross-sectional and longitudinal findings in the main MS clinical phenotypes and in different brain tissues: focal white matter (WM) lesions, normal-appearing white matter (NAWM), cortical gray matter (GM), and deep normal-appearing gray matter (NAGM). We also discuss the clinical associations, possible reasons for conflicting results, correlations with other MRI-based measures, and histopathological associations. We highlight the limitations of the biomarker itself and the methodology of each study. Finally, we update the reader on its potential use as an imaging biomarker in research.
KW - Biomarker
KW - T1/T2-weighted ratio
KW - magnetic resonance imaging
KW - multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85186565452&partnerID=8YFLogxK
U2 - 10.1177/13524585241233448
DO - 10.1177/13524585241233448
M3 - Review article
C2 - 38389172
SN - 1352-4585
VL - 30
SP - 283
EP - 291
JO - MULTIPLE SCLEROSIS JOURNAL
JF - MULTIPLE SCLEROSIS JOURNAL
IS - 3
ER -