Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review

Oren Lapid; Jan J. van Wingerden; Leon Perlemuter

doi:https://doi.org/10.1515/jpem-2013-0052

Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review

Oren Lapid, Jan J. van Wingerden, Leon Perlemuter

Research output: Contribution to journal › Review article › Academic › peer-review

30 Citations (Scopus)

Abstract

Objective: A systematic review to assess the efficacy of tamoxifen in the management of idiopathic pubertal gynecomastia. Data sources: Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science (R). Study selection: Studies reporting the use of Tamoxifen for the treatment of gynecomastia in adolescents. Outcome measure: Resolution of gynecomastia. Results: A total of 164 publications were found; 59 were selected for retrieval and six were included in the review. There were no randomized controlled studies; the studies found have methodological flaws but show promising results. No clinical side-effects were reported or observed. Conclusion: Tamoxifen may be effective for the treatment of pubertal gynecomastia, and it seems safe to use. Randomized controlled studies are necessary to confirm this indication

Original language	English
Pages (from-to)	803-807
Journal	Journal of pediatric endocrinology & metabolism
Volume	26
Issue number	9-10
DOIs	https://doi.org/10.1515/jpem-2013-0052
Publication status	Published - 2013

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https://doi.org/10.1515/jpem-2013-0052

Cite this

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title = "Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review",

abstract = "Objective: A systematic review to assess the efficacy of tamoxifen in the management of idiopathic pubertal gynecomastia. Data sources: Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science (R). Study selection: Studies reporting the use of Tamoxifen for the treatment of gynecomastia in adolescents. Outcome measure: Resolution of gynecomastia. Results: A total of 164 publications were found; 59 were selected for retrieval and six were included in the review. There were no randomized controlled studies; the studies found have methodological flaws but show promising results. No clinical side-effects were reported or observed. Conclusion: Tamoxifen may be effective for the treatment of pubertal gynecomastia, and it seems safe to use. Randomized controlled studies are necessary to confirm this indication",

author = "Oren Lapid and {van Wingerden}, {Jan J.} and Leon Perlemuter",

year = "2013",

doi = "https://doi.org/10.1515/jpem-2013-0052",

language = "English",

volume = "26",

pages = "803--807",

journal = "Journal of pediatric endocrinology & metabolism",

issn = "0334-018X",

publisher = "Walter de Gruyter GmbH",

number = "9-10",

}

TY - JOUR

T1 - Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review

AU - Lapid, Oren

AU - van Wingerden, Jan J.

AU - Perlemuter, Leon

PY - 2013

Y1 - 2013

N2 - Objective: A systematic review to assess the efficacy of tamoxifen in the management of idiopathic pubertal gynecomastia. Data sources: Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science (R). Study selection: Studies reporting the use of Tamoxifen for the treatment of gynecomastia in adolescents. Outcome measure: Resolution of gynecomastia. Results: A total of 164 publications were found; 59 were selected for retrieval and six were included in the review. There were no randomized controlled studies; the studies found have methodological flaws but show promising results. No clinical side-effects were reported or observed. Conclusion: Tamoxifen may be effective for the treatment of pubertal gynecomastia, and it seems safe to use. Randomized controlled studies are necessary to confirm this indication

AB - Objective: A systematic review to assess the efficacy of tamoxifen in the management of idiopathic pubertal gynecomastia. Data sources: Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science (R). Study selection: Studies reporting the use of Tamoxifen for the treatment of gynecomastia in adolescents. Outcome measure: Resolution of gynecomastia. Results: A total of 164 publications were found; 59 were selected for retrieval and six were included in the review. There were no randomized controlled studies; the studies found have methodological flaws but show promising results. No clinical side-effects were reported or observed. Conclusion: Tamoxifen may be effective for the treatment of pubertal gynecomastia, and it seems safe to use. Randomized controlled studies are necessary to confirm this indication

U2 - https://doi.org/10.1515/jpem-2013-0052

DO - https://doi.org/10.1515/jpem-2013-0052

M3 - Review article

C2 - 23729603

SN - 0334-018X

VL - 26

SP - 803

EP - 807

JO - Journal of pediatric endocrinology & metabolism

JF - Journal of pediatric endocrinology & metabolism

IS - 9-10

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