@article{68300fb26e7644dcb3b517a8f5edee20,
title = "TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti",
abstract = "The auditory function of the mammalian cochlea relies on two types of mechanosensory hair cells and various non-sensory supporting cells. Recent studies identified the transcription factors INSM1 and IKZF2 as regulators of outer hair cell (OHC) fate. However, the transcriptional regulation of the differentiation of inner hair cells (IHCs) and their associated inner supporting cells (ISCs) has remained enigmatic. Here, we show that the expression of the transcription factor TBX2 is restricted to IHCs and ISCs from the onset of differentiation until adulthood and examine its function using conditional deletion and misexpression approaches in the mouse. We demonstrate that TBX2 acts in prosensory progenitors as a patterning factor by specifying the inner compartment of the sensory epithelium that subsequently gives rise to IHCs and ISCs. Hair cell-specific inactivation or misexpression causes transdifferentiation of hair cells indicating a cell-autonomous function of TBX2 in inducing and maintaining IHC fate.",
author = "Marina Kaiser and L{\"u}dtke, {Timo H.} and Lena Deuper and Carsten Rudat and Christoffels, {Vincent M.} and Andreas Kispert and Mark-Oliver Trowe",
note = "Funding Information: The monoclonal antibody against CDH2 (clone: MNCD2) developed by Takeichi, M./Matsunami, H. was obtained from the Developmental Studies Hybridoma Bank, created by the NICHD of the NIH and maintained at The University of Iowa, Department of Biology, Iowa City, IA 52242. We thank the Research Core Unit Transcriptomics of Hannover Medical School for microarray analysis, and Achim Gossler for critical reading of the manuscript. This work was supported by the German Research Council (Deutsche Forschungsgemeinschaft) [DFG TR1325/1-1 to M.-O.T.]. Funding Information: The monoclonal antibody against CDH2 (clone: MNCD2) developed by Takeichi, M./Matsunami, H. was obtained from the Developmental Studies Hybridoma Bank, created by the NICHD of the NIH and maintained at The University of Iowa, Department of Biology, Iowa City, IA 52242. We thank the Research Core Unit Transcriptomics of Hannover Medical School for microarray analysis, and Achim Gossler for critical reading of the manuscript. This work was supported by the German Research Council (Deutsche Forschungsgemeinschaft) [DFG TR1325/1-1 to M.-O.T.]. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
day = "1",
doi = "https://doi.org/10.1038/s41467-022-35214-4",
language = "English",
volume = "13",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}