TY - JOUR
T1 - Telephone and Smartphone-Based Interventions for Cognitive and Cardio-Metabolic Health in Middle-Aged and Older Adults
T2 - A Systematic Review
AU - Andre, Laurine
AU - Giulioli, Caroline
AU - Piau, Antoine
AU - Bongard, Vanina
AU - Richard, Edo
AU - Moll van Charante, Eric P.
AU - Coley, Nicola
AU - Andrieu, Sandrine
N1 - Funding Information: Barnes, Rachael Brooks (University of Cambridge, Cambridge, UK); Wei Wang, Wenzhi Wang, Youxin Wang, Manshu Song (Capital Medical University, Beijing, China; Edith Cowan University (ECU), Perth Australia); Anders Wimo, Ron Handels (Karolinska Institutet, Stockholm, Sweden); Sandrine Andrieu, Nicola Coley (INSERM UMR1295, Toulouse France); Jean Georges, Cindy Birck (Alzheimer Europe, Luxembourg); Bram van de Groep, Rick Mast (Vital Health Software, Ede, the Netherlands). The present work was also performed in the context of the Inspire Program, a research platform supported by grants from the Region Occitanie/Pyrénées-Méditerranée (Reference number: 1901175) and the European Regional Development Fund (ERDF) (Project number: MP0022856). Funding Information: This review was performed as part of the Prodemos Project. The research leading to these results has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no 779238 and the National Key R&D Programme of China (2017YFE0118800). The members of the PRODEMOS group are: Edo Richard, Pim van Gool, Eric Moll van Charante, Marieke Hoevenaar-Blom, Esmé Eggink, Melanie Hafdi, Patrick Witvliet (Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands); Carol Brayne, Linda Publisher Copyright: © 2022 Andre et al. This work is published and licens.
PY - 2022
Y1 - 2022
N2 - Purpose: Dementia and cardio-metabolic diseases share many risk factors. Management of these risk factors could contribute to successful aging, including the prevention of cardio-metabolic disease and dementia. The increasing use of smartphones offers an opportunity for remote preventive interventions. We provided a systematic review of telephone and smartphone-based interventions targeting the prevention of cognitive decline, dementia cardio-metabolic diseases or their risk factors among adults aged over 50 years. Patients and Methods: We searched Pubmed and the International Clinical Trials Registry Platform for experimental studies. We used the Cochrane risk-of-bias tool (Version 2) for randomized trials or TREND (Transparent Reporting of Evaluations with Nonrandomized Designs) checklists to assess study quality for completed studies. Results: We analyzed 21 completed (3 for cognition, 18 for cardio-metabolic outcomes) and 50 ongoing studies (23 for cognition, 27 for cardio-metabolic outcomes). Smartphone interventions were used in 26 studies (3 completed, 23 ongoing). Other interventions involved telephone vocal support and text messaging. Few studies were at low risk of bias. There were heterogeneous cognitive and cardio-metabolic outcomes. The highest quality studies found no significant effects on cognition, and inconsistent results for HbA1c, blood pressure or physical activity. The lower quality-studies found effects on global cognition, working memory, memory and language and inconsistent results for clinical, biological or behavioral cardio-metabolic outcomes. Conclusion and Implications: Despite the large number of commercially available mobile health applications, the magnitude of the scientific evidence base remains very limited. Based on published studies, the added value of telephone and smartphone tools for the prevention of cardio-metabolic diseases, cognitive decline or dementia is currently uncertain, but, there are several ongoing studies expected to be completed in the coming years.
AB - Purpose: Dementia and cardio-metabolic diseases share many risk factors. Management of these risk factors could contribute to successful aging, including the prevention of cardio-metabolic disease and dementia. The increasing use of smartphones offers an opportunity for remote preventive interventions. We provided a systematic review of telephone and smartphone-based interventions targeting the prevention of cognitive decline, dementia cardio-metabolic diseases or their risk factors among adults aged over 50 years. Patients and Methods: We searched Pubmed and the International Clinical Trials Registry Platform for experimental studies. We used the Cochrane risk-of-bias tool (Version 2) for randomized trials or TREND (Transparent Reporting of Evaluations with Nonrandomized Designs) checklists to assess study quality for completed studies. Results: We analyzed 21 completed (3 for cognition, 18 for cardio-metabolic outcomes) and 50 ongoing studies (23 for cognition, 27 for cardio-metabolic outcomes). Smartphone interventions were used in 26 studies (3 completed, 23 ongoing). Other interventions involved telephone vocal support and text messaging. Few studies were at low risk of bias. There were heterogeneous cognitive and cardio-metabolic outcomes. The highest quality studies found no significant effects on cognition, and inconsistent results for HbA1c, blood pressure or physical activity. The lower quality-studies found effects on global cognition, working memory, memory and language and inconsistent results for clinical, biological or behavioral cardio-metabolic outcomes. Conclusion and Implications: Despite the large number of commercially available mobile health applications, the magnitude of the scientific evidence base remains very limited. Based on published studies, the added value of telephone and smartphone tools for the prevention of cardio-metabolic diseases, cognitive decline or dementia is currently uncertain, but, there are several ongoing studies expected to be completed in the coming years.
KW - aging
KW - cardio
KW - cognition
KW - dementia
KW - smartphone
KW - telephone
KW - vascular outcomes
UR - http://www.scopus.com/inward/record.url?scp=85141661300&partnerID=8YFLogxK
U2 - https://doi.org/10.2147/CIA.S352137
DO - https://doi.org/10.2147/CIA.S352137
M3 - Review article
C2 - 36393902
SN - 1176-9092
VL - 17
SP - 1599
EP - 1624
JO - Clinical Interventions in Aging
JF - Clinical Interventions in Aging
ER -