TY - JOUR
T1 - Temperature-dependent optical properties of individual vascular wall components measured by optical coherence tomography
AU - van der Meer, Freek J.
AU - Faber, Dirk J.
AU - Cilesiz, Inci
AU - van Gemert, Martin J. C.
AU - van Leeuwen, Ton G.
PY - 2006
Y1 - 2006
N2 - Optical properties of tissues and tissue components are important parameters in biomedical optics. We report measurements of tissue refractive index n and the attenuation coefficient mu(t) using optical coherence tomography (OCT) of individual vascular wall layers and plaque components. Moreover, since the temperature dependence of optical properties is widely known, we compare measurements at room and body temperatures. A decrease of n and mu(t) is observed in all samples, with the most profound effect on samples with high lipid content. The sample temperature is of influence on the quantitative measurements within OCT images. For extrapolation of ex-vivo experimental results, especially for structures with high lipid content, this effect should be taken into account
AB - Optical properties of tissues and tissue components are important parameters in biomedical optics. We report measurements of tissue refractive index n and the attenuation coefficient mu(t) using optical coherence tomography (OCT) of individual vascular wall layers and plaque components. Moreover, since the temperature dependence of optical properties is widely known, we compare measurements at room and body temperatures. A decrease of n and mu(t) is observed in all samples, with the most profound effect on samples with high lipid content. The sample temperature is of influence on the quantitative measurements within OCT images. For extrapolation of ex-vivo experimental results, especially for structures with high lipid content, this effect should be taken into account
U2 - https://doi.org/10.1117/1.2333613
DO - https://doi.org/10.1117/1.2333613
M3 - Article
C2 - 16965148
SN - 1083-3668
VL - 11
SP - 041120
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 4
ER -