TY - JOUR
T1 - Temporal changes in left ventricular longitudinal strain in general population: Clinical correlates and impact on cardiac remodeling
AU - Kuznetsova, Tatiana
AU - Nijs, Ellen
AU - Cauwenberghs, Nicholas
AU - Knez, Judita
AU - Thijs, Lutgarde
AU - Haddad, Francois
AU - Yang, Wen-Yi
AU - Kerkhof, Peter L.
AU - Voigt, Jens-Uwe
AU - Staessen, Jan A.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Background: Recent studies in patients and general population have reported the role of left ventricular (LV) longitudinal strain (LS) as an independent predictor of outcome. However, there are few data on changes in LS over time. We therefore investigated in a general population clinical correlates of temporal changes in LS. We also explored the potential correlation between temporal changes in LV volumes and LS. Methods and Results: We measured LV end-systolic (ESV) and end-diastolic (EDV) volumes by conventional echocardiography and LS by 2D speckle tracking in 627 participants (mean age 50.6 years, 51.4% women; 41.3% hypertensives) at baseline and after 4.7 years. For statistical analysis, we used the absolute values of LS. In stepwise regression, the magnitude of the decrease in all LV LS indexes over time was greater in men than in women (P < 0.0001). Higher baseline mean arterial pressure (MAP), a larger longitudinal increase in MAP, and stopping diuretic treatment during follow-up were related to larger decreases in LS indexes. In multivariable-adjusted analysis, we observed an inverse correlation between baseline ESV and LV LS (P ≤ 0.0017). Similarly, lower baseline LS and a larger decrease in LS over time were correlated with a lesser longitudinal decrease in ESV (P ≤ 0.0004). Conclusions: A significant decrease in LS over time was associated with male sex, higher baseline MAP, ∆MAP, and alteration in antihypertensive treatment. We suggested an interaction between a longitudinal decrease in LV deformation and adverse cardiac remodeling, while underscoring the importance of deformation analysis based on LS assessment in patients at risk.
AB - Background: Recent studies in patients and general population have reported the role of left ventricular (LV) longitudinal strain (LS) as an independent predictor of outcome. However, there are few data on changes in LS over time. We therefore investigated in a general population clinical correlates of temporal changes in LS. We also explored the potential correlation between temporal changes in LV volumes and LS. Methods and Results: We measured LV end-systolic (ESV) and end-diastolic (EDV) volumes by conventional echocardiography and LS by 2D speckle tracking in 627 participants (mean age 50.6 years, 51.4% women; 41.3% hypertensives) at baseline and after 4.7 years. For statistical analysis, we used the absolute values of LS. In stepwise regression, the magnitude of the decrease in all LV LS indexes over time was greater in men than in women (P < 0.0001). Higher baseline mean arterial pressure (MAP), a larger longitudinal increase in MAP, and stopping diuretic treatment during follow-up were related to larger decreases in LS indexes. In multivariable-adjusted analysis, we observed an inverse correlation between baseline ESV and LV LS (P ≤ 0.0017). Similarly, lower baseline LS and a larger decrease in LS over time were correlated with a lesser longitudinal decrease in ESV (P ≤ 0.0004). Conclusions: A significant decrease in LS over time was associated with male sex, higher baseline MAP, ∆MAP, and alteration in antihypertensive treatment. We suggested an interaction between a longitudinal decrease in LV deformation and adverse cardiac remodeling, while underscoring the importance of deformation analysis based on LS assessment in patients at risk.
KW - cardiac remodeling
KW - general population
KW - left ventricular strain
KW - longitudinal changes
KW - systolic function
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059593872&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30609050
U2 - https://doi.org/10.1111/echo.14246
DO - https://doi.org/10.1111/echo.14246
M3 - Article
C2 - 30609050
SN - 0742-2822
VL - 36
SP - 458
EP - 468
JO - Echocardiography
JF - Echocardiography
IS - 3
ER -