Abstract
We present 2 human immunodeficiency virus-infected patients with tenofovir disoproxil fumarate-induced Fanconi syndrome, leading to osteomalacia. Intracellular tenofovir diphosphate levels were measured in 1 patient and were found to be very high, with plasma tenofovir levels just slightly elevated. Fibroblast growth factor-23, a phosphaturic hormone, was decreased in both patients and is therefore unlikely to have a pathophysiological role in this pathology. The different potential factors contributing to the development of tenofovir-related kidney proximal tubular dysfunction are discussed and the data presented may help to further elucidate its pathogenesis. © 2011 Informa Healthcare.
Original language | English |
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Pages (from-to) | 821-826 |
Journal | Scandinavian journal of infectious diseases |
Volume | 43 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2011 |