TY - JOUR
T1 - Tertiary Lymphoid Structures: Diversity in Their Development, Composition, and Role
T2 - Diversity in Their Development, Composition, and Role
AU - Gago da Graça, Catarina
AU - van Baarsen, Lisa G. M.
AU - Mebius, Reina E.
N1 - Funding Information: This work was supported by Netherlands Organisation for Health Research and Development (NWO ZonMw) TOP Grant 91217014 (to R.E.M. and L.G.M.v.B). Publisher Copyright: Copyright © 2021 by The American Association of Immunologists, Inc. All rights reserved.
PY - 2021/1/15
Y1 - 2021/1/15
N2 - Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid organs, providing both a structural matrix and soluble factors that regulate survival and migration of immune cells, ultimately promoting Ag encounter. In several inflamed tissues, resident fibroblasts can acquire lymphoid-stroma properties and drive the formation of ectopic aggregates of immune cells, named tertiary lymphoid structures (TLSs). Mature TLSs are functional sites for the development of adaptive responses and, consequently, when present, can have an impact in both autoimmunity and cancer conditions. In this review, we go over recent findings concerning both lymph node stromal cells and TLSs function and formation and further describe what is currently known about their role in disease, particularly their potential in tolerance.
AB - Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid organs, providing both a structural matrix and soluble factors that regulate survival and migration of immune cells, ultimately promoting Ag encounter. In several inflamed tissues, resident fibroblasts can acquire lymphoid-stroma properties and drive the formation of ectopic aggregates of immune cells, named tertiary lymphoid structures (TLSs). Mature TLSs are functional sites for the development of adaptive responses and, consequently, when present, can have an impact in both autoimmunity and cancer conditions. In this review, we go over recent findings concerning both lymph node stromal cells and TLSs function and formation and further describe what is currently known about their role in disease, particularly their potential in tolerance.
UR - http://www.scopus.com/inward/record.url?scp=85099332233&partnerID=8YFLogxK
U2 - https://doi.org/10.4049/jimmunol.2000873
DO - https://doi.org/10.4049/jimmunol.2000873
M3 - Review article
C2 - 33397741
SN - 0022-1767
VL - 206
SP - 273
EP - 281
JO - Journal of immunology (Baltimore, Md.
JF - Journal of immunology (Baltimore, Md.
IS - 2
ER -