TY - JOUR
T1 - Testicular cancer in Europe and the USA: Survival still rising among older patients
AU - Verhoeven, R. H. A.
AU - Gondos, Adam
AU - Janssen-heijnen, M. L. G.
AU - Saum, K. U.
AU - Brewster, D. H.
AU - Holleczek, Bernd
AU - Crocetti, Emanuele
AU - Rosso, Stefano
AU - Hakulinen, Timo
AU - Aareleid, T.
AU - Brenner, Hermann
AU - Aareleid, Tiiu
AU - Bray, Freddie
AU - Coebergh, Jan Willem
AU - Janssen-Heijnen, Maryska
AU - Mägi, Margit
AU - Rachtan, Jadwiga
AU - Smailyte, Giedre
AU - Usel, Massimo
AU - Žakelj, Maja Primic
AU - Brewster, David
PY - 2013/2
Y1 - 2013/2
N2 - Background: Despite high curability, some testicular cancer (TC) patient groups may have increased mortality. We provide a detailed age- and histology-specific comparison of population-based relative survival of TC patients in Europe and the USA. Design: Using data from 12 European cancer registries and the USA Surveillance, Epidemiology and End Results 9 database, we report survival trends for patients diagnosed with testicular seminomas and nonseminomas between 1993-1997 and 2003-2007. Additionally, a model-based analysis was used to compare survival trends and relative excess risk (RER) of death between Europe and the USA adjusting for differences in age and histology. Results: In 2003-2007, the 5-year relative survival of patients with testicular seminoma was at least 98% among those aged <50 years, survival of patients with nonseminoma remained 3%-6% units lower.Despite improvements in the relative survival of nonseminoma patients aged ≥50 years by 13%-18% units, survival remained markedly lower than the survival of seminoma patients of the same age. Model-based analyses showed increased RERs for nonseminomas, older, and European patients. Conclusions: There remains little room for survival improvement among testicular seminoma patients, especially for those aged <50 years. Older TC patients remain at increased risk of death, which seems mainly attributable to the lower survival among the nonseminoma patients. © The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
AB - Background: Despite high curability, some testicular cancer (TC) patient groups may have increased mortality. We provide a detailed age- and histology-specific comparison of population-based relative survival of TC patients in Europe and the USA. Design: Using data from 12 European cancer registries and the USA Surveillance, Epidemiology and End Results 9 database, we report survival trends for patients diagnosed with testicular seminomas and nonseminomas between 1993-1997 and 2003-2007. Additionally, a model-based analysis was used to compare survival trends and relative excess risk (RER) of death between Europe and the USA adjusting for differences in age and histology. Results: In 2003-2007, the 5-year relative survival of patients with testicular seminoma was at least 98% among those aged <50 years, survival of patients with nonseminoma remained 3%-6% units lower.Despite improvements in the relative survival of nonseminoma patients aged ≥50 years by 13%-18% units, survival remained markedly lower than the survival of seminoma patients of the same age. Model-based analyses showed increased RERs for nonseminomas, older, and European patients. Conclusions: There remains little room for survival improvement among testicular seminoma patients, especially for those aged <50 years. Older TC patients remain at increased risk of death, which seems mainly attributable to the lower survival among the nonseminoma patients. © The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873845778&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/23110807
U2 - https://doi.org/10.1093/annonc/mds460
DO - https://doi.org/10.1093/annonc/mds460
M3 - Article
C2 - 23110807
SN - 0923-7534
VL - 24
SP - 508
EP - 513
JO - Annals of Oncology
JF - Annals of Oncology
IS - 2
ER -