Thalamic Deep Brain Stimulation for Orthostatic Tremor: A Multicenter International Registry

Aristide Merola; Alfonso Fasano; Anhar Hassan; Jill L. Ostrem; Maria Fiorella Contarino; Mark Lyons; Joachim K. Krauss; Marc E. Wolf; Bryan T. Klassen; Anne-Fleur van Rootselaar; Ignacio Regidor; Andrew P. Duker; William Ondo; Jorge Guridi; Jens Volkmann; Aparna Wagle Shukla; George T. Mandybur; Michael S. Okun; Karsten Witt; Philip A. Starr; Günther Deuschl; Alberto J. Espay

doi:https://doi.org/10.1002/mds.27082

Thalamic Deep Brain Stimulation for Orthostatic Tremor: A Multicenter International Registry

Aristide Merola, Alfonso Fasano, Anhar Hassan, Jill L. Ostrem, Maria Fiorella Contarino, Mark Lyons, Joachim K. Krauss, Marc E. Wolf, Bryan T. Klassen, Anne-Fleur van Rootselaar, Ignacio Regidor, Andrew P. Duker, William Ondo, Jorge Guridi, Jens Volkmann, Aparna Wagle Shukla, George T. Mandybur, Michael S. Okun, Karsten Witt, Philip A. StarrGünther Deuschl, Alberto J. Espay

Research output: Contribution to journal › Article › Academic › peer-review

27 Citations (Scopus)

Abstract

Background: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (>= 48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications. Results: There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the shortterm (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions: Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor. (C) 2017 International

Original language	English
Pages (from-to)	1240-1244
Journal	Movement disorders
Volume	32
Issue number	8
Early online date	2017
DOIs	https://doi.org/10.1002/mds.27082
Publication status	Published - 2017

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Merola, A., Fasano, A., Hassan, A., Ostrem, J. L., Contarino, M. F., Lyons, M., Krauss, J. K., Wolf, M. E., Klassen, B. T., van Rootselaar, A.-F., Regidor, I., Duker, A. P., Ondo, W., Guridi, J., Volkmann, J., Wagle Shukla, A., Mandybur, G. T., Okun, M. S., Witt, K., ... Espay, A. J. (2017). Thalamic Deep Brain Stimulation for Orthostatic Tremor: A Multicenter International Registry. Movement disorders, 32(8), 1240-1244. https://doi.org/10.1002/mds.27082

@article{0c0ffe48ab4d4dc983ad5870077833b6,

title = "Thalamic Deep Brain Stimulation for Orthostatic Tremor: A Multicenter International Registry",

abstract = "Background: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (>= 48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications. Results: There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the shortterm (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions: Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor. (C) 2017 International",

author = "Aristide Merola and Alfonso Fasano and Anhar Hassan and Ostrem, {Jill L.} and Contarino, {Maria Fiorella} and Mark Lyons and Krauss, {Joachim K.} and Wolf, {Marc E.} and Klassen, {Bryan T.} and {van Rootselaar}, Anne-Fleur and Ignacio Regidor and Duker, {Andrew P.} and William Ondo and Jorge Guridi and Jens Volkmann and {Wagle Shukla}, Aparna and Mandybur, {George T.} and Okun, {Michael S.} and Karsten Witt and Starr, {Philip A.} and G{\"u}nther Deuschl and Espay, {Alberto J.}",

year = "2017",

doi = "https://doi.org/10.1002/mds.27082",

language = "English",

volume = "32",

pages = "1240--1244",

journal = "Movement disorders",

issn = "0885-3185",

publisher = "John Wiley and Sons Inc.",

number = "8",

}

Merola, A, Fasano, A, Hassan, A, Ostrem, JL, Contarino, MF, Lyons, M, Krauss, JK, Wolf, ME, Klassen, BT, van Rootselaar, A-F, Regidor, I, Duker, AP, Ondo, W, Guridi, J, Volkmann, J, Wagle Shukla, A, Mandybur, GT, Okun, MS, Witt, K, Starr, PA, Deuschl, G & Espay, AJ 2017, 'Thalamic Deep Brain Stimulation for Orthostatic Tremor: A Multicenter International Registry', Movement disorders, vol. 32, no. 8, pp. 1240-1244. https://doi.org/10.1002/mds.27082

TY - JOUR

T1 - Thalamic Deep Brain Stimulation for Orthostatic Tremor: A Multicenter International Registry

AU - Merola, Aristide

AU - Fasano, Alfonso

AU - Hassan, Anhar

AU - Ostrem, Jill L.

AU - Contarino, Maria Fiorella

AU - Lyons, Mark

AU - Krauss, Joachim K.

AU - Wolf, Marc E.

AU - Klassen, Bryan T.

AU - van Rootselaar, Anne-Fleur

AU - Regidor, Ignacio

AU - Duker, Andrew P.

AU - Ondo, William

AU - Guridi, Jorge

AU - Volkmann, Jens

AU - Wagle Shukla, Aparna

AU - Mandybur, George T.

AU - Okun, Michael S.

AU - Witt, Karsten

AU - Starr, Philip A.

AU - Deuschl, Günther

AU - Espay, Alberto J.

PY - 2017

Y1 - 2017

N2 - Background: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (>= 48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications. Results: There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the shortterm (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions: Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor. (C) 2017 International

AB - Background: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (>= 48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications. Results: There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the shortterm (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions: Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor. (C) 2017 International

U2 - https://doi.org/10.1002/mds.27082

DO - https://doi.org/10.1002/mds.27082

M3 - Article

C2 - 28631862

SN - 0885-3185

VL - 32

SP - 1240

EP - 1244

JO - Movement disorders

JF - Movement disorders

IS - 8

ER -