Thalidomide opnieuw in de belangstelling

Translated title of the contribution: Thalidomide once more topical

L. T W De Jong-Van Den Berg, J. Rutgers, M. C. Cornel

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)


Thalidomide was withdrawn from the market in the early sixties because of major teratogenic effects such as reduction defects of the limbs. Since, however, it has been found to be an effective drug in erythema nodosum leprosum. In the United States it was decided in September 1997 to admit thalidomide to the market for this indication, and in South America it has been available for this indication all the time. Thalidomide is also efficacious in other major disorders (e.g. aphtae and ulcers in aids) or its efficacy is being investigated in clinical trials (e.g. autoimmune diseases, other complications in aids). The American Food and Drug Administration has imposed conditions for the use of thalidomide. Users have to sign an informed consent and to take adequate contraceptive measures. Physicians should inform the patients and monitor side effects. Pharmacists should record and control the use.

Translated title of the contributionThalidomide once more topical
Original languageDutch
Pages (from-to)2509-2512
Number of pages4
JournalNederlands Tijdschrift voor Geneeskunde
Issue number46
Publication statusPublished - 14 Nov 1998
Externally publishedYes

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