TY - JOUR
T1 - The 2023 Orthopedic Research Society's international consensus meeting on musculoskeletal infection
T2 - Summary from the in vitro section
AU - Hickok, Noreen J.
AU - Li, Bingyun
AU - Oral, Ebru
AU - Zaat, Sebastian A. J.
AU - Armbruster, David A.
AU - Atkins, Gerald J.
AU - Chen, Antonia F.
AU - Coraça-Huber, D. bora C.
AU - Dai, Tianhong
AU - Greenfield, Edward M.
AU - Kasinath, Rajendra
AU - Libera, Matthew
AU - Marques, Cláudia N. H.
AU - Moriarty, T. Fintan
AU - Scott Phillips, K.
AU - Raghuraman, Kapil
AU - Ren, Dacheng
AU - Rimondini, Lia
AU - Saeed, Kordo
AU - Schaer, Thomas P.
AU - Schwarz, Edward M.
AU - Spiegel, Christopher
AU - Stoodley, Paul
AU - Truong, Vi Khanh
AU - Tsang, Shao-Ting Jerry
AU - Wildemann, Britt
AU - Zelmer, Anja R.
AU - Zinkernagel, Annelies S.
N1 - Publisher Copyright: © 2024 The Authors. Journal of Orthopaedic Research® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.
PY - 2024/3
Y1 - 2024/3
N2 - Antimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopedic Research Society Musculoskeletal Infection international consensus meeting (ICM) probed our state of knowledge of in vitro systems with respect to bacteria and biofilm phenotype, standards, in vitro activity, and the ability to predict in vivo efficacy. A subset of ICM delegates performed systematic reviews on 15 questions and made recommendations and assessment of the level of evidence that were then voted on by 72 ICM delegates. Here, we report recommendations and rationale from the reviews and the results of the internet vote. Only two questions received a ≥90% consensus vote, emphasizing the disparate approaches and lack of established consensus for in vitro modeling and interpretation of results. Comments on knowledge gaps and the need for further research on these critical MSKI questions are included.
AB - Antimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopedic Research Society Musculoskeletal Infection international consensus meeting (ICM) probed our state of knowledge of in vitro systems with respect to bacteria and biofilm phenotype, standards, in vitro activity, and the ability to predict in vivo efficacy. A subset of ICM delegates performed systematic reviews on 15 questions and made recommendations and assessment of the level of evidence that were then voted on by 72 ICM delegates. Here, we report recommendations and rationale from the reviews and the results of the internet vote. Only two questions received a ≥90% consensus vote, emphasizing the disparate approaches and lack of established consensus for in vitro modeling and interpretation of results. Comments on knowledge gaps and the need for further research on these critical MSKI questions are included.
KW - antimicrobial
KW - biofilm
KW - in vitro models
KW - international consensus meeting (ICM)
KW - musculoskeletal infection (MSKI)
UR - http://www.scopus.com/inward/record.url?scp=85182857067&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/jor.25774
DO - https://doi.org/10.1002/jor.25774
M3 - Article
C2 - 38146070
SN - 0736-0266
VL - 42
SP - 512
EP - 517
JO - Journal of orthopaedic research
JF - Journal of orthopaedic research
IS - 3
ER -