The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Joseph D. Khoury; Eric Solary; Oussama Abla; Yassmine Akkari; Rita Alaggio; Jane F. Apperley; Rafael Bejar; Emilio Berti; Lambert Busque; John K. C. Chan; Weina Chen; Xueyan Chen; Wee-Joo Chng; John K. Choi; Isabel Colmenero; Sarah E. Coupland; Nicholas C. P. Cross; Daphne de Jong; M. Tarek Elghetany; Emiko Takahashi; Jean-Francois Emile; Judith Ferry; Linda Fogelstrand; Michaela Fontenay; Ulrich Germing; Sumeet Gujral; Torsten Haferlach; Claire Harrison; Jennelle C. Hodge; Shimin Hu; Joop H. Jansen; Rashmi Kanagal-Shamanna; Hagop M. Kantarjian; Christian P. Kratz; Xiao-Qiu Li; Megan S. Lim; Keith Loeb; Sanam Loghavi; Andrea Marcogliese; Soheil Meshinchi; Phillip Michaels; Kikkeri N. Naresh; Yasodha Natkunam; Reza Nejati; German Ott; Eric Padron; Keyur P. Patel; Nikhil Patkar; Jennifer Picarsic; Uwe Platzbecker; Irene Roberts; Anna Schuh; William Sewell; Reiner Siebert; Prashant Tembhare; Jeffrey Tyner; Srdan Verstovsek; Wei Wang; Brent Wood; Wenbin Xiao; Cecilia Yeung; Andreas Hochhaus

doi:https://doi.org/10.1038/s41375-022-01613-1

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

Joseph D. Khoury, Eric Solary, Oussama Abla, Yassmine Akkari, Rita Alaggio, Jane F. Apperley, Rafael Bejar, Emilio Berti, Lambert Busque, John K. C. Chan, Weina Chen, Xueyan Chen, Wee-Joo Chng, John K. Choi, Isabel Colmenero, Sarah E. Coupland, Nicholas C. P. Cross, Daphne de Jong, M. Tarek Elghetany, Emiko TakahashiJean-Francois Emile, Judith Ferry, Linda Fogelstrand, Michaela Fontenay, Ulrich Germing, Sumeet Gujral, Torsten Haferlach, Claire Harrison, Jennelle C. Hodge, Shimin Hu, Joop H. Jansen, Rashmi Kanagal-Shamanna, Hagop M. Kantarjian, Christian P. Kratz, Xiao-Qiu Li, Megan S. Lim, Keith Loeb, Sanam Loghavi, Andrea Marcogliese, Soheil Meshinchi, Phillip Michaels, Kikkeri N. Naresh, Yasodha Natkunam, Reza Nejati, German Ott, Eric Padron, Keyur P. Patel, Nikhil Patkar, Jennifer Picarsic, Uwe Platzbecker, Irene Roberts, Anna Schuh, William Sewell, Reiner Siebert, Prashant Tembhare, Jeffrey Tyner, Srdan Verstovsek, Wei Wang, Brent Wood, Wenbin Xiao, Cecilia Yeung, Andreas Hochhaus

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.

Original language	English
Pages (from-to)	1703-1719
Number of pages	17
Journal	Leukemia
Volume	36
Issue number	7
DOIs	https://doi.org/10.1038/s41375-022-01613-1
Publication status	Published - 1 Jul 2022

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Khoury, J. D., Solary, E., Abla, O., Akkari, Y., Alaggio, R., Apperley, J. F., Bejar, R., Berti, E., Busque, L., Chan, J. K. C., Chen, W., Chen, X., Chng, W.-J., Choi, J. K., Colmenero, I., Coupland, S. E., Cross, N. C. P., de Jong, D., Elghetany, M. T., ... Hochhaus, A. (2022). The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia, 36(7), 1703-1719. https://doi.org/10.1038/s41375-022-01613-1

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title = "The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms",

abstract = "The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.",

author = "Khoury, {Joseph D.} and Eric Solary and Oussama Abla and Yassmine Akkari and Rita Alaggio and Apperley, {Jane F.} and Rafael Bejar and Emilio Berti and Lambert Busque and Chan, {John K. C.} and Weina Chen and Xueyan Chen and Wee-Joo Chng and Choi, {John K.} and Isabel Colmenero and Coupland, {Sarah E.} and Cross, {Nicholas C. P.} and {de Jong}, Daphne and Elghetany, {M. Tarek} and Emiko Takahashi and Jean-Francois Emile and Judith Ferry and Linda Fogelstrand and Michaela Fontenay and Ulrich Germing and Sumeet Gujral and Torsten Haferlach and Claire Harrison and Hodge, {Jennelle C.} and Shimin Hu and Jansen, {Joop H.} and Rashmi Kanagal-Shamanna and Kantarjian, {Hagop M.} and Kratz, {Christian P.} and Xiao-Qiu Li and Lim, {Megan S.} and Keith Loeb and Sanam Loghavi and Andrea Marcogliese and Soheil Meshinchi and Phillip Michaels and Naresh, {Kikkeri N.} and Yasodha Natkunam and Reza Nejati and German Ott and Eric Padron and Patel, {Keyur P.} and Nikhil Patkar and Jennifer Picarsic and Uwe Platzbecker and Irene Roberts and Anna Schuh and William Sewell and Reiner Siebert and Prashant Tembhare and Jeffrey Tyner and Srdan Verstovsek and Wei Wang and Brent Wood and Wenbin Xiao and Cecilia Yeung and Andreas Hochhaus",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = jul,

day = "1",

doi = "https://doi.org/10.1038/s41375-022-01613-1",

language = "English",

volume = "36",

pages = "1703--1719",

journal = "Leukemia",

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Khoury, JD, Solary, E, Abla, O, Akkari, Y, Alaggio, R, Apperley, JF, Bejar, R, Berti, E, Busque, L, Chan, JKC, Chen, W, Chen, X, Chng, W-J, Choi, JK, Colmenero, I, Coupland, SE, Cross, NCP, de Jong, D, Elghetany, MT, Takahashi, E, Emile, J-F, Ferry, J, Fogelstrand, L, Fontenay, M, Germing, U, Gujral, S, Haferlach, T, Harrison, C, Hodge, JC, Hu, S, Jansen, JH, Kanagal-Shamanna, R, Kantarjian, HM, Kratz, CP, Li, X-Q, Lim, MS, Loeb, K, Loghavi, S, Marcogliese, A, Meshinchi, S, Michaels, P, Naresh, KN, Natkunam, Y, Nejati, R, Ott, G, Padron, E, Patel, KP, Patkar, N, Picarsic, J, Platzbecker, U, Roberts, I, Schuh, A, Sewell, W, Siebert, R, Tembhare, P, Tyner, J, Verstovsek, S, Wang, W, Wood, B, Xiao, W, Yeung, C & Hochhaus, A 2022, 'The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms', Leukemia, vol. 36, no. 7, pp. 1703-1719. https://doi.org/10.1038/s41375-022-01613-1

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T1 - The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours

T2 - Myeloid and Histiocytic/Dendritic Neoplasms

AU - Khoury, Joseph D.

AU - Solary, Eric

AU - Abla, Oussama

AU - Akkari, Yassmine

AU - Alaggio, Rita

AU - Apperley, Jane F.

AU - Bejar, Rafael

AU - Berti, Emilio

AU - Busque, Lambert

AU - Chan, John K. C.

AU - Chen, Weina

AU - Chen, Xueyan

AU - Chng, Wee-Joo

AU - Choi, John K.

AU - Colmenero, Isabel

AU - Coupland, Sarah E.

AU - Cross, Nicholas C. P.

AU - de Jong, Daphne

AU - Elghetany, M. Tarek

AU - Takahashi, Emiko

AU - Emile, Jean-Francois

AU - Ferry, Judith

AU - Fogelstrand, Linda

AU - Fontenay, Michaela

AU - Germing, Ulrich

AU - Gujral, Sumeet

AU - Haferlach, Torsten

AU - Harrison, Claire

AU - Hodge, Jennelle C.

AU - Hu, Shimin

AU - Jansen, Joop H.

AU - Kanagal-Shamanna, Rashmi

AU - Kantarjian, Hagop M.

AU - Kratz, Christian P.

AU - Li, Xiao-Qiu

AU - Lim, Megan S.

AU - Loeb, Keith

AU - Loghavi, Sanam

AU - Marcogliese, Andrea

AU - Meshinchi, Soheil

AU - Michaels, Phillip

AU - Naresh, Kikkeri N.

AU - Natkunam, Yasodha

AU - Nejati, Reza

AU - Ott, German

AU - Padron, Eric

AU - Patel, Keyur P.

AU - Patkar, Nikhil

AU - Picarsic, Jennifer

AU - Platzbecker, Uwe

AU - Roberts, Irene

AU - Schuh, Anna

AU - Sewell, William

AU - Siebert, Reiner

AU - Tembhare, Prashant

AU - Tyner, Jeffrey

AU - Verstovsek, Srdan

AU - Wang, Wei

AU - Wood, Brent

AU - Xiao, Wenbin

AU - Yeung, Cecilia

AU - Hochhaus, Andreas

PY - 2022/7/1

Y1 - 2022/7/1

N2 - The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.

AB - The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought where possible, the classification strives to keep practical worldwide applicability in perspective. The result is an enhanced, contemporary, evidence-based classification of myeloid and histiocytic/dendritic neoplasms, rooted in molecular biology and an organizational structure that permits future scalability as new discoveries continue to inexorably inform future editions.

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U2 - https://doi.org/10.1038/s41375-022-01613-1

DO - https://doi.org/10.1038/s41375-022-01613-1

M3 - Review article

C2 - 35732831

SN - 0887-6924

VL - 36

SP - 1703

EP - 1719

JO - Leukemia

JF - Leukemia

IS - 7

ER -

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

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