The Activation of Microglia as an Early Sign of Disease Progression in Alzheimer's Disease

Robert Veerhuis; Jeroen J.M. Hoozemans; Annachiara Cagnin; Piet Eikelenboom; Richard B. Banati

doi:https://doi.org/10.1093/acprof:oso/9780195152227.003.0045

The Activation of Microglia as an Early Sign of Disease Progression in Alzheimer's Disease

Robert Veerhuis, Jeroen J.M. Hoozemans, Annachiara Cagnin, Piet Eikelenboom, Richard B. Banati

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

This chapter focuses on the contribution of activated microglia to the progression of Alzheimer's disease (AD) at various stages of the pathological cascade. Clusters of activated microglia occur only in complement-positive amyloidβ (Aβ) plaques, and effector functions of complement include the modulation of microglial activity in vitro. It addresses the question of whether microglia are detrimental or beneficial in AD pathogenesis, especially in relation to the presence and modulating activities of activation products of the complement system.

Original language	English
Title of host publication	Neuroglia
Publisher	The Oxford University Press
ISBN (Electronic)	9780199865024
ISBN (Print)	0195152220, 9780195152227
DOIs	https://doi.org/10.1093/acprof:oso/9780195152227.003.0045
Publication status	Published - 1 Sept 2013

Keywords

Activated microglia
Alzheimer's disease
Amyloidβ
Plaque

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https://doi.org/10.1093/acprof:oso/9780195152227.003.0045

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The Activation of Microglia as an Early Sign of Disease Progression in Alzheimer's Disease

Abstract

Keywords

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