TY - JOUR
T1 - The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function
AU - van der Meer, Rutger W.
AU - Rijzewijk, Luuk J.
AU - Diamant, Michaela
AU - Hammer, Sebastiaan
AU - Schär, Michael
AU - Bax, Jeroen J.
AU - Smit, Johannes W. A.
AU - Romijn, Johannes A.
AU - de Roos, Albert
AU - Lamb, Hildo J.
AU - Schar, M.
PY - 2008
Y1 - 2008
N2 - In animal models of obesity and diabetes mellitus, myocardial TG accumulation is associated with decreased myocardial function. In the physiologically ageing heart, myocardial triglyceride (TG) accumulation may also occur due to reduced myocardial fatty acid oxidation. The role of myocardial TG in the ageing human heart is unknown. Therefore, the purpose of our study was to evaluate the effects of ageing on myocardial TG content, and to determine the association between myocardial TG content and heart function. 1H-magnetic resonance spectroscopy and magnetic resonance imaging of the heart were performed in 43 healthy male subjects. Mean age (range) of the subjects was 44 (20-66) years. Body mass index (BMI), blood pressure, and biochemical markers were determined. Age correlated significantly to myocardial TG content (r = 0.57, P <0.05) independently of BMI. Furthermore, myocardial TG content correlated negatively with left ventricular diastolic function (represented by E/A ratio, r = -0.68, P <0.05). Multivariable analysis indicated myocardial TG content as independent predictor (P <0.05) of the age related decrease in diastolic heart function. Myocardial TG content increases in the physiologically ageing male heart and is associated with the age-related decline in diastolic function, independent of BMI, blood pressure, and biochemical blood markers
AB - In animal models of obesity and diabetes mellitus, myocardial TG accumulation is associated with decreased myocardial function. In the physiologically ageing heart, myocardial triglyceride (TG) accumulation may also occur due to reduced myocardial fatty acid oxidation. The role of myocardial TG in the ageing human heart is unknown. Therefore, the purpose of our study was to evaluate the effects of ageing on myocardial TG content, and to determine the association between myocardial TG content and heart function. 1H-magnetic resonance spectroscopy and magnetic resonance imaging of the heart were performed in 43 healthy male subjects. Mean age (range) of the subjects was 44 (20-66) years. Body mass index (BMI), blood pressure, and biochemical markers were determined. Age correlated significantly to myocardial TG content (r = 0.57, P <0.05) independently of BMI. Furthermore, myocardial TG content correlated negatively with left ventricular diastolic function (represented by E/A ratio, r = -0.68, P <0.05). Multivariable analysis indicated myocardial TG content as independent predictor (P <0.05) of the age related decrease in diastolic heart function. Myocardial TG content increases in the physiologically ageing male heart and is associated with the age-related decline in diastolic function, independent of BMI, blood pressure, and biochemical blood markers
U2 - https://doi.org/10.1093/eurheartj/ehn207
DO - https://doi.org/10.1093/eurheartj/ehn207
M3 - Article
C2 - 18492680
SN - 0195-668X
VL - 29
SP - 1516
EP - 1522
JO - European Heart journal
JF - European Heart journal
IS - 12
ER -