TY - JOUR
T1 - The anatomy, development, and evolution of the atrioventricular conduction axis
AU - Anderson, Robert H.
AU - Mori, Shumpei
AU - Spicer, Diane E.
AU - Sanchez-Quintana, Damian
AU - Jensen, Bjarke
N1 - Publisher Copyright: © 2018 by the authors.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - It is now well over 100 years since Sunao Tawara clarified the location of the axis of the specialised myocardium responsible for producing coordinated ventricular activation. Prior to that stellar publication, controversies had raged as to how many bundles crossed the place of the atrioventricular insulation as found in mammalian hearts, as well as the very existence of the bundle initially described byWilhelm His Junior. It is, perhaps surprising that controversies continue, despite the multiple investigations that have taken place since the publication of Tawara's monograph. For example, we are still unsure as to the precise substrates for the so-called slow and fast pathways into the atrioventricular node. Much has been done, nonetheless, to characterise the molecular make-up of the specialised pathways, and to clarify their mechanisms of development. Of this work itself, a significant part has emanated from the laboratory coordinated for a quarter of a century by Antoon FM Moorman. In this review, which joins the others in recognising the value of his contributions and collaborations, we review our current understanding of the anatomy, development, and evolution of the atrioventricular conduction axis.
AB - It is now well over 100 years since Sunao Tawara clarified the location of the axis of the specialised myocardium responsible for producing coordinated ventricular activation. Prior to that stellar publication, controversies had raged as to how many bundles crossed the place of the atrioventricular insulation as found in mammalian hearts, as well as the very existence of the bundle initially described byWilhelm His Junior. It is, perhaps surprising that controversies continue, despite the multiple investigations that have taken place since the publication of Tawara's monograph. For example, we are still unsure as to the precise substrates for the so-called slow and fast pathways into the atrioventricular node. Much has been done, nonetheless, to characterise the molecular make-up of the specialised pathways, and to clarify their mechanisms of development. Of this work itself, a significant part has emanated from the laboratory coordinated for a quarter of a century by Antoon FM Moorman. In this review, which joins the others in recognising the value of his contributions and collaborations, we review our current understanding of the anatomy, development, and evolution of the atrioventricular conduction axis.
KW - Atrioventricular node
KW - Bundle of His
KW - Dead-end tract
KW - Retroaortic node
KW - Ventricular bundle branches
UR - http://www.scopus.com/inward/record.url?scp=85072181400&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/jcdd5030044
DO - https://doi.org/10.3390/jcdd5030044
M3 - Review article
C2 - 30135383
SN - 2308-3425
VL - 5
JO - Journal of cardiovascular development and disease
JF - Journal of cardiovascular development and disease
IS - 3
M1 - E44
ER -