TY - JOUR
T1 - The anti-ischaemic activity of the novel compound, CERM 11956, compared with that of bepridil and nifedipine in isolated guinea-pig hearts
AU - Boddeke, Erik W.G.M.
AU - Wilffert, Bob
AU - Heynis, Jaap B.
AU - Hugtenburg, Jacqueline G.
AU - Jap, Walther T.J.
AU - Veldsema-Currie, Robin D.
AU - Van Zwieten, Pieter A.
PY - 1988/5/10
Y1 - 1988/5/10
N2 - A comparison between the protective activity of bedridil, its novel derivative, CERM 11956, and nifedipine in isolated electrically paced guinea-pig hearts after 60 min of global ischaemia followed by 30 min of reperfusion has been made. All three compounds exerted a significant anti-ischaemic effect, as indicated by an improved recovery of functional parameters (left ventricular pressure and coronary perfusion), a delayed onset of the ischaemic contracture, and an enhanced recovery of biochemical (CrP, ATP and adenylate energy charge) parameters. The most pronounced anti-ischaemic activity was shown by the compound CERM 11956 at concentrations that displayed only minor negative inotropic activity. From the results it may be concluded that the new bepridil derivative, CERM 11956, is a promising and potent anti-ischaemic compound, which has little influence on haemodynamic parameters.
AB - A comparison between the protective activity of bedridil, its novel derivative, CERM 11956, and nifedipine in isolated electrically paced guinea-pig hearts after 60 min of global ischaemia followed by 30 min of reperfusion has been made. All three compounds exerted a significant anti-ischaemic effect, as indicated by an improved recovery of functional parameters (left ventricular pressure and coronary perfusion), a delayed onset of the ischaemic contracture, and an enhanced recovery of biochemical (CrP, ATP and adenylate energy charge) parameters. The most pronounced anti-ischaemic activity was shown by the compound CERM 11956 at concentrations that displayed only minor negative inotropic activity. From the results it may be concluded that the new bepridil derivative, CERM 11956, is a promising and potent anti-ischaemic compound, which has little influence on haemodynamic parameters.
KW - Bepridil
KW - CERM 11956
KW - Ischaemia (global)
UR - http://www.scopus.com/inward/record.url?scp=0023925653&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/0014-2999(88)90649-8
DO - https://doi.org/10.1016/0014-2999(88)90649-8
M3 - Article
C2 - 3261692
SN - 0014-2999
VL - 149
SP - 195
EP - 203
JO - European journal of pharmacology
JF - European journal of pharmacology
IS - 3
ER -