TY - JOUR
T1 - The applicability of antidepressants in the depressed medically ill
T2 - an open clinical trial with fluoxetine
AU - Huyse, Frits J.
AU - Zwaan, Wilhelm A.
AU - Kupka, Ralph
PY - 1994/10
Y1 - 1994/10
N2 - In the literature the side-effects and medical complications of tricyclic antidepressants (TCAs), in the medically ill have been extensively reviewed. This study uses a prospective design to examine these issues' questions in an almost solely in-patient C-L population (N=37) treated with a serotinergic antidepressant (fluoxetine). A first remarkable finding is the fact that 83% of the patients have complaints comparable with the side-effects of the drug, prior to its administration. Second, although the drop-out rates (DO) are comparable with those in earlier studies, in this study DO do not seem to be related to the seriousness of the side-effects of the drug. The more serious side-effects were hyponatremia (N=1) and gastrointestinal symptoms (N=3). In contrast to TCAs no psychiatric side-effects have to be reported. Therefore this study suggests that with good medical supervision fluoxetine can be used in the treatment of seriously medically ill patients with depressive co-morbidity.
AB - In the literature the side-effects and medical complications of tricyclic antidepressants (TCAs), in the medically ill have been extensively reviewed. This study uses a prospective design to examine these issues' questions in an almost solely in-patient C-L population (N=37) treated with a serotinergic antidepressant (fluoxetine). A first remarkable finding is the fact that 83% of the patients have complaints comparable with the side-effects of the drug, prior to its administration. Second, although the drop-out rates (DO) are comparable with those in earlier studies, in this study DO do not seem to be related to the seriousness of the side-effects of the drug. The more serious side-effects were hyponatremia (N=1) and gastrointestinal symptoms (N=3). In contrast to TCAs no psychiatric side-effects have to be reported. Therefore this study suggests that with good medical supervision fluoxetine can be used in the treatment of seriously medically ill patients with depressive co-morbidity.
UR - http://www.scopus.com/inward/record.url?scp=0028079706&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/0022-3999(94)90022-1
DO - https://doi.org/10.1016/0022-3999(94)90022-1
M3 - Article
C2 - 7877124
SN - 0022-3999
VL - 38
SP - 695
EP - 703
JO - Journal of psychosomatic research
JF - Journal of psychosomatic research
IS - 7
ER -