The association between birth weight and plasma fibrinogen is abolished after the elimination of genetic influences

R.G. IJzerman, C.D.A. Stehouwer, E.J.C. de Geus, C. Kluft, D.I. Boomsma, D. I. Boomsmay

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11 Citations (Scopus)


Low birth weight is associated with an increased risk of atherothrombosis, which may be related in part to the association between low birth weight and high plasma fibrinogen. The association between birth weight and fibrinogen may be explained by intrauterine, socio-economic or genetic factors. We examined birth weight and fibrinogen in 52 dizygotic and 56 adolescent monozygotic (genetically identical) twin pairs. The dizygotic but not the monozygotic twins with the lowest birth weight from each pair had a fibrinogen level that was higher compared with their co-twins with the highest birth weight [dizygotic twins: 2.62±0.46 g L
Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalJournal of thrombosis and haemostasis
Issue number2
Publication statusPublished - 1 Feb 2003


  • Birth weight
  • Fibrinogen
  • Genetics
  • Twins

Cohort Studies

  • Netherlands Twin Register (NTR)

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