TY - JOUR
T1 - The association between frailty and MRI features of cerebral small vessel disease
AU - Kant, Ilse M. J.
AU - Mutsaerts, Henri J. M. M.
AU - van Montfort, Simone J. T.
AU - Jaarsma-Coes, Myriam G.
AU - Witkamp, Theodoor D.
AU - Winterer, Georg
AU - Spies, Claudia D.
AU - Hendrikse, Jeroen
AU - Slooter, Arjen J. C.
AU - de Bresser, Jeroen
AU - Armbruster, Franz Paul
AU - Böcher, Axel
AU - Boraschi, Diana
AU - Borchers, Friedrich
AU - Della Camera, Giacomo
AU - van Dellen, Edwin
AU - Diehl, Ina
AU - Dschietzig, Thomas Bernd
AU - Feinkohl, Insa
AU - Fillmer, Ariane
AU - Gallinat, J. rgen
AU - Hafen, Bettina
AU - Hartmann, Katarina
AU - Heidtke, Karsten
AU - Helmschrodt, Anja
AU - Italiani, Paola
AU - Ittermann, Bernd
AU - Krause, Roland
AU - Kronabel, Marion
AU - Kühn, Simone
AU - Lachmann, Gunnar
AU - Melillo, Daniela
AU - Menon, David K.
AU - Moreno-López, Laura
AU - Mörgeli, Rudolf
AU - Nürnberg, Peter
AU - Ofosu, Kwaku
AU - Olbert, Maria
AU - Pietzsch, Malte
AU - Pischon, Tobias
AU - Preller, Jacobus
AU - Ruppert, Jana
AU - Schneider, Reinhard
AU - Stamatakis, Emmanuel A.
AU - Weber, Simon
AU - Weyer, Marius
AU - Winzeck, Stefan
AU - Wolf, Alissa
AU - Yürek, Fatima
AU - BioCog Consortium
AU - van Dellen, Edwin
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Frailty is a common syndrome in older individuals that is associated with poor cognitive outcome. The underlying brain correlates of frailty are unclear. The aim of this study was to investigate the association between frailty and MRI features of cerebral small vessel disease in a group of non-demented older individuals. We included 170 participants who were classified as frail (n = 30), pre-frail (n = 85) or non-frail (n = 55). The association of frailty and white matter hyperintensity volume and shape features, lacunar infarcts and cerebral perfusion was investigated by regression analyses adjusted for age and sex. Frail and pre-frail participants were older, more often female and showed higher white matter hyperintensity volume (0.69 [95%-CI 0.08 to 1.31], p = 0.03 respectively 0.43 [95%-CI: 0.04 to 0.82], p = 0.03) compared to non-frail participants. Frail participants showed a non-significant trend, and pre-frail participants showed a more complex shape of white matter hyperintensities (concavity index: 0.04 [95%-CI: 0.03 to 0.08], p = 0.03; fractal dimensions: 0.07 [95%-CI: 0.00 to 0.15], p = 0.05) compared to non-frail participants. No between group differences were found in gray matter perfusion or in the presence of lacunar infarcts. In conclusion, increased white matter hyperintensity volume and a more complex white matter hyperintensity shape may be structural brain correlates of the frailty phenotype.
AB - Frailty is a common syndrome in older individuals that is associated with poor cognitive outcome. The underlying brain correlates of frailty are unclear. The aim of this study was to investigate the association between frailty and MRI features of cerebral small vessel disease in a group of non-demented older individuals. We included 170 participants who were classified as frail (n = 30), pre-frail (n = 85) or non-frail (n = 55). The association of frailty and white matter hyperintensity volume and shape features, lacunar infarcts and cerebral perfusion was investigated by regression analyses adjusted for age and sex. Frail and pre-frail participants were older, more often female and showed higher white matter hyperintensity volume (0.69 [95%-CI 0.08 to 1.31], p = 0.03 respectively 0.43 [95%-CI: 0.04 to 0.82], p = 0.03) compared to non-frail participants. Frail participants showed a non-significant trend, and pre-frail participants showed a more complex shape of white matter hyperintensities (concavity index: 0.04 [95%-CI: 0.03 to 0.08], p = 0.03; fractal dimensions: 0.07 [95%-CI: 0.00 to 0.15], p = 0.05) compared to non-frail participants. No between group differences were found in gray matter perfusion or in the presence of lacunar infarcts. In conclusion, increased white matter hyperintensity volume and a more complex white matter hyperintensity shape may be structural brain correlates of the frailty phenotype.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070194245&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31383903
U2 - https://doi.org/10.1038/s41598-019-47731-2
DO - https://doi.org/10.1038/s41598-019-47731-2
M3 - Article
C2 - 31383903
SN - 2045-2322
VL - 9
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 11343
ER -