TY - JOUR
T1 - The chromosomal passenger complex
T2 - Guiding Aurora-B through mitosis
AU - Vader, Gerben
AU - Medema, René H.
AU - Lens, Susanne M.A.
PY - 2006/6/27
Y1 - 2006/6/27
N2 - During mitosis, the chromosomal passenger complex (CPC) orchestrates highly different processes, such as chromosome alignment, histone modification, and cytokinesis. Proper and timely localization of this complex is the key to precise control over the enzymatic core of the CPC, the Aurora-B kinase. We discuss the molecular mechanisms by which the CPC members direct the dynamic localization of the complex throughout cell division. Also, we summarize posttranslational modifications that occur on the CPC and discuss their roles in regulating localization and function of this mitotic complex.
AB - During mitosis, the chromosomal passenger complex (CPC) orchestrates highly different processes, such as chromosome alignment, histone modification, and cytokinesis. Proper and timely localization of this complex is the key to precise control over the enzymatic core of the CPC, the Aurora-B kinase. We discuss the molecular mechanisms by which the CPC members direct the dynamic localization of the complex throughout cell division. Also, we summarize posttranslational modifications that occur on the CPC and discuss their roles in regulating localization and function of this mitotic complex.
UR - http://www.scopus.com/inward/record.url?scp=33745275629&partnerID=8YFLogxK
U2 - https://doi.org/10.1083/jcb.200604032
DO - https://doi.org/10.1083/jcb.200604032
M3 - Short survey
C2 - 16769825
SN - 0021-9525
VL - 173
SP - 833
EP - 837
JO - Journal of cell biology
JF - Journal of cell biology
IS - 6
ER -