TY - JOUR
T1 - The chronnectome as a model for Charcot's ‘dynamic lesion’ in functional movement disorders
AU - Marapin, Ramesh S.
AU - van der Stouwe, A. M. Madelein
AU - de Jong, Bauke M.
AU - Gelauff, Jeannette M.
AU - Vergara, Victor M.
AU - Calhoun, Vince D.
AU - Dalenberg, Jelle R.
AU - Dreissen, Yasmine E. M.
AU - Koelman, Johannes H. T. M.
AU - Tijssen, Marina A. J.
AU - van der Horn, Harm J.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - This exploratory study set out to investigate dynamic functional connectivity (dFC) in patients with jerky and tremulous functional movement disorders (JT-FMD). The focus in this work is on dynamic brain states, which represent distinct dFC patterns that reoccur in time and across subjects. Resting-state fMRI data were collected from 17 patients with JT-FMD and 17 healthy controls (HC). Symptom severity was measured using the Clinical Global Impression-Severity scale. Depression and anxiety were measured using the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), respectively. Independent component analysis was used to extract functional brain components. After computing dFC, dynamic brain states were determined for every subject using k-means clustering. Compared to HC, patients with JT-FMD spent more time in a state that was characterized predominantly by increasing medial prefrontal, and decreasing posterior midline connectivity over time. They also tended to visit this state more frequently. In addition, patients with JT-FMD transitioned significantly more often between different states compared to HC, and incorporated a state with decreasing medial prefrontal, and increasing posterior midline connectivity in their attractor, i.e., the cyclic patterns of state transitions. Altogether, this is the first study that demonstrates altered functional brain network dynamics in JT-FMD that may support concepts of increased self-reflective processes and impaired sense of agency as driving factors in FMD.
AB - This exploratory study set out to investigate dynamic functional connectivity (dFC) in patients with jerky and tremulous functional movement disorders (JT-FMD). The focus in this work is on dynamic brain states, which represent distinct dFC patterns that reoccur in time and across subjects. Resting-state fMRI data were collected from 17 patients with JT-FMD and 17 healthy controls (HC). Symptom severity was measured using the Clinical Global Impression-Severity scale. Depression and anxiety were measured using the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), respectively. Independent component analysis was used to extract functional brain components. After computing dFC, dynamic brain states were determined for every subject using k-means clustering. Compared to HC, patients with JT-FMD spent more time in a state that was characterized predominantly by increasing medial prefrontal, and decreasing posterior midline connectivity over time. They also tended to visit this state more frequently. In addition, patients with JT-FMD transitioned significantly more often between different states compared to HC, and incorporated a state with decreasing medial prefrontal, and increasing posterior midline connectivity in their attractor, i.e., the cyclic patterns of state transitions. Altogether, this is the first study that demonstrates altered functional brain network dynamics in JT-FMD that may support concepts of increased self-reflective processes and impaired sense of agency as driving factors in FMD.
KW - Brain dynamics
KW - Brain networks
KW - Functional connectivity
KW - Functional movement disorders
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=85090570687&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.nicl.2020.102381
DO - https://doi.org/10.1016/j.nicl.2020.102381
M3 - Article
C2 - 32927233
SN - 2213-1582
VL - 28
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 102381
ER -