TY - JOUR
T1 - The Cognitive-Functional Composite is sensitive to clinical progression in early dementia
T2 - Longitudinal findings from the Catch-Cog study cohort
AU - Jutten, Roos J.
AU - Harrison, John E.
AU - Brunner, A. J.
AU - Vreeswijk, R.
AU - van Deelen, R. A.J.
AU - de Jong, Frank Jan
AU - Opmeer, Esther M.
AU - Ritchie, Craig W.
AU - Aleman, André
AU - Scheltens, Philip
AU - Sikkes, Sietske A.M.
PY - 2020
Y1 - 2020
N2 - Introduction: In an attempt to capture clinically meaningful cognitive decline in early dementia, we developed the Cognitive-Functional Composite (CFC). We investigated the CFC's sensitivity to decline in comparison to traditional clinical endpoints. Methods: This longitudinal construct validation study included 148 participants with subjective cognitive decline, mild cognitive impairment, or mild dementia. The CFC and traditional tests were administered at baseline, 3, 6, and 12 months. Sensitivity to change was investigated using linear mixed models and r2 effect sizes. Results: CFC scores declined over time (β = −.16, P <.001), with steepest decline observed in mild Alzheimer's dementia (β = −.25, P <.001). The CFC showed medium-to-large effect sizes at succeeding follow-up points (r2=.08-.42), exhibiting greater change than the Clinical Dementia Rating scale (r2=.02-.12). Moreover, change on the CFC was significantly associated with informant reports of cognitive decline (β =.38, P <.001). Discussion: By showing sensitivity to decline, the CFC could enhance the monitoring of disease progression in dementia research and clinical practice.
AB - Introduction: In an attempt to capture clinically meaningful cognitive decline in early dementia, we developed the Cognitive-Functional Composite (CFC). We investigated the CFC's sensitivity to decline in comparison to traditional clinical endpoints. Methods: This longitudinal construct validation study included 148 participants with subjective cognitive decline, mild cognitive impairment, or mild dementia. The CFC and traditional tests were administered at baseline, 3, 6, and 12 months. Sensitivity to change was investigated using linear mixed models and r2 effect sizes. Results: CFC scores declined over time (β = −.16, P <.001), with steepest decline observed in mild Alzheimer's dementia (β = −.25, P <.001). The CFC showed medium-to-large effect sizes at succeeding follow-up points (r2=.08-.42), exhibiting greater change than the Clinical Dementia Rating scale (r2=.02-.12). Moreover, change on the CFC was significantly associated with informant reports of cognitive decline (β =.38, P <.001). Discussion: By showing sensitivity to decline, the CFC could enhance the monitoring of disease progression in dementia research and clinical practice.
KW - Alzheimer's disease
KW - cognition
KW - dementia
KW - instrumental activities of daily living
KW - mild cognitive impairment
KW - outcome measures
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U2 - https://doi.org/10.1002/trc2.12020
DO - https://doi.org/10.1002/trc2.12020
M3 - Article
C2 - 32313832
SN - 2352-8737
VL - 6
SP - 1
EP - 11
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
IS - 1
M1 - e12020
ER -
