Abstract
The complement (C) system plays a central role in innate immunity and bridges innate and adaptive immune responses. A fine balance of C activation and regulation mediates the elimination of invading pathogens and the protection of the host from excessive C deposition on healthy tissues. If this delicate balance is disrupted, the C system may cause injury and contribute to the pathogenesis of various diseases, including neuropathies. Here we review evidence indicating that C factors and regulators are locally synthesized in the peripheral nerve and we discuss the evidence supporting the protective or detrimental role of C activation in health, injury and disease of the peripheral nerve. (C) 2008 Elsevier Ltd. All rights reserved
Original language | English |
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Pages (from-to) | 3865-3877 |
Journal | Molecular immunology |
Volume | 45 |
Issue number | 15 |
DOIs | |
Publication status | Published - 2008 |