TY - JOUR
T1 - The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer
T2 - the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors
AU - Verdonck-de Leeuw, Irma M
AU - Korsten, Laura H A
AU - van Nieuwenhuizen, Annette
AU - Baatenburg de Jong, Rob J
AU - Brakenhoff, Ruud H
AU - Buffart, Laurien M
AU - Lamers, Femke
AU - Langendijk, Johannes A
AU - Leemans, C René
AU - Smit, Jan H
AU - Sprangers, Mirjam A
AU - Takes, Robert P
AU - Terhaard, Chris H J
AU - Lissenberg-Witte, Birgit I
AU - Jansen, Femke
N1 - © 2023. The Author(s).
PY - 2023/7/11
Y1 - 2023/7/11
N2 - PURPOSE: The aim of this prospective cohort study was to estimate the relationship between the course of HRQOL in the first 2 years after diagnosis and treatment of head and neck cancer (HNC) and personal, clinical, psychological, physical, social, lifestyle, HNC-related, and biological factors.METHODS: Data were used from 638 HNC patients of the NETherlands QUality of life and BIomedical Cohort study (NET-QUBIC). Linear mixed models were used to investigate factors associated with the course of HRQOL (EORTC QLQ-C30 global quality of life (QL) and summary score (SumSc)) from baseline to 3, 6, 12, and 24 months after treatment.RESULTS: Baseline depressive symptoms, social contacts, and oral pain were significantly associated with the course of QL from baseline to 24 months. Tumor subsite and baseline social eating, stress (hyperarousal), coughing, feeling ill, and IL-10 were associated with the course of SumSc. Post-treatment social contacts and stress (avoidance) were significantly associated with the course of QL from 6 to 24 months, and social contacts and weight loss with the course of SumSc. The course of SumSc from 6 to 24 months was also significantly associated with a change in financial problems, speech problems, weight loss, and shoulder problems between baseline and 6 months.CONCLUSION: Baseline clinical, psychological, social, lifestyle, HNC-related, and biological factors are associated with the course of HRQOL from baseline to 24 months after treatment. Post-treatment social, lifestyle, and HNC-related factors are associated with the course of HRQOL from 6 to 24 months after treatment.
AB - PURPOSE: The aim of this prospective cohort study was to estimate the relationship between the course of HRQOL in the first 2 years after diagnosis and treatment of head and neck cancer (HNC) and personal, clinical, psychological, physical, social, lifestyle, HNC-related, and biological factors.METHODS: Data were used from 638 HNC patients of the NETherlands QUality of life and BIomedical Cohort study (NET-QUBIC). Linear mixed models were used to investigate factors associated with the course of HRQOL (EORTC QLQ-C30 global quality of life (QL) and summary score (SumSc)) from baseline to 3, 6, 12, and 24 months after treatment.RESULTS: Baseline depressive symptoms, social contacts, and oral pain were significantly associated with the course of QL from baseline to 24 months. Tumor subsite and baseline social eating, stress (hyperarousal), coughing, feeling ill, and IL-10 were associated with the course of SumSc. Post-treatment social contacts and stress (avoidance) were significantly associated with the course of QL from 6 to 24 months, and social contacts and weight loss with the course of SumSc. The course of SumSc from 6 to 24 months was also significantly associated with a change in financial problems, speech problems, weight loss, and shoulder problems between baseline and 6 months.CONCLUSION: Baseline clinical, psychological, social, lifestyle, HNC-related, and biological factors are associated with the course of HRQOL from baseline to 24 months after treatment. Post-treatment social, lifestyle, and HNC-related factors are associated with the course of HRQOL from 6 to 24 months after treatment.
KW - Biological Factors
KW - Cohort Studies
KW - Cortisol
KW - Head and Neck Neoplasms/therapy
KW - Head and neck cancer
KW - Health-related quality of life
KW - Humans
KW - Inflammation
KW - Life Style
KW - Prospective Studies
KW - Quality of Life
KW - Stress
KW - Weight Loss
UR - http://www.scopus.com/inward/record.url?scp=85164292245&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00520-023-07918-w
DO - https://doi.org/10.1007/s00520-023-07918-w
M3 - Article
C2 - 37432446
SN - 0941-4355
VL - 31
SP - 458
JO - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
IS - 8
M1 - 458
ER -