TY - JOUR
T1 - The crosstalk between microbiome and asthma
T2 - Exploring associations and challenges
AU - Abdel-Aziz, M.I.
AU - Vijverberg, S.J.H.
AU - Neerincx, A.H.
AU - Kraneveld, A.D.
AU - Maitland-van der Zee, A.H.
N1 - Funding Information: AHM has been reimbursed for visiting the ATS by Chiesi, AHM received a fee for participating in advisory boards for Boehringer lngelheim and Astra Zeneca, and AHM received an unrestricted research grant from GSK. ADK received grants/research support from several companies ao Janssen, GSK, Nutricia Research, Friesland Campina and NTRC. Publisher Copyright: © 2019 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons Ltd
PY - 2019
Y1 - 2019
N2 - © 2019 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons LtdWith the advancement of high-throughput DNA/RNA sequencing and computational analysis techniques, commensal bacteria are now considered almost as important as pathological ones. Understanding the interaction between these bacterial microbiota, host and asthma is crucial to reveal their role in asthma pathophysiology. Several airway and/or gut microbiome studies have shown associations between certain bacterial taxa and asthma. However, challenges remain before gained knowledge from these studies can be implemented into clinical practice, such as inconsistency between studies in choosing sampling compartments and/or sequencing approaches, variability of results in asthma studies, and not taking into account medication intake and diet composition especially when investigating gut microbiome. Overcoming those challenges will help to better understand the complex asthma disease process. The therapeutic potential of using pro- and prebiotics to prevent or reduce risk of asthma exacerbations requires further investigation. This review will focus on methodological issues regarding setting up a microbiome study, recent developments in asthma bacterial microbiome studies, challenges and future therapeutic potential.
AB - © 2019 The Authors. Clinical & Experimental Allergy Published by John Wiley & Sons LtdWith the advancement of high-throughput DNA/RNA sequencing and computational analysis techniques, commensal bacteria are now considered almost as important as pathological ones. Understanding the interaction between these bacterial microbiota, host and asthma is crucial to reveal their role in asthma pathophysiology. Several airway and/or gut microbiome studies have shown associations between certain bacterial taxa and asthma. However, challenges remain before gained knowledge from these studies can be implemented into clinical practice, such as inconsistency between studies in choosing sampling compartments and/or sequencing approaches, variability of results in asthma studies, and not taking into account medication intake and diet composition especially when investigating gut microbiome. Overcoming those challenges will help to better understand the complex asthma disease process. The therapeutic potential of using pro- and prebiotics to prevent or reduce risk of asthma exacerbations requires further investigation. This review will focus on methodological issues regarding setting up a microbiome study, recent developments in asthma bacterial microbiome studies, challenges and future therapeutic potential.
KW - asthma
KW - clinical immunology
KW - omics- and systems biology
KW - regulatory aspects
UR - http://www.scopus.com/inward/record.url?scp=85070189734&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070189734&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31148278
U2 - https://doi.org/10.1111/cea.13444
DO - https://doi.org/10.1111/cea.13444
M3 - Review article
C2 - 31148278
SN - 0954-7894
VL - 49
SP - 1067
EP - 1086
JO - Clinical and experimental allergy
JF - Clinical and experimental allergy
IS - 8
ER -