The decreased serum activity of cytosolic 5′-nucleotidase IA as a potential marker of breast cancer-associated muscle inflammation

Agata Jędrzejewska, Barbara Kutryb-Zając, Oliwia Król, Gabriela Harasim, Marika Frańczak, Patrycja Jabłońska, Ewa Słomińska, Ryszard Tomasz Smoleński

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Cytosolic 5′-nucleotidase IA (cN-IA) plays a central role in the regulation of the purine nucleotide pool in skeletal muscle, preferentially converting adenosine monophosphate to adenosine. cN-IA can act as an autoantigen in muscle diseases, including the paraneoplastic syndrome related to breast cancer (BC). As a result of myocyte damage, released cN-IA protein may trigger the production of anti-cN-IA antibodies (anti-NT5C1A). This work aimed to develop an effective method to measure cN-IA activity in the serum and analyze it in BC patients. Our study demonstrated that serum cN-IA activity was decreased in BC patients and we assumed it is due to the presence of specific autoantibodies. We found correlations between cN-IA activity and parameters of inflammatory muscle damage. Thus, cN-IA is worth further attention to clarify its usefulness as a biomarker of BC-associated polymyositis.
Original languageEnglish
Pages (from-to)273-284
JournalNucleosides, Nucleotides and Nucleic Acids
Issue number3
Publication statusPublished - 2022

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