The Diagnostic Value of the Sentinel Node Procedure to Detect Occult Lymph Node Metastases in PSMA PET/CT Node–Negative Prostate Cancer Patients

Jan J. Duin; Hilda A. de Barros; Maarten L. Donswijk; Eva E. Schaake; Tim M. van der Sluis; Esther M. K. Wit; Fijs W. B. van Leeuwen; Pim J. van Leeuwen; Henk G. van der Poel

doi:https://doi.org/10.2967/jnumed.123.265556

The Diagnostic Value of the Sentinel Node Procedure to Detect Occult Lymph Node Metastases in PSMA PET/CT Node–Negative Prostate Cancer Patients

Jan J. Duin, Hilda A. de Barros, Maarten L. Donswijk, Eva E. Schaake, Tim M. van der Sluis, Esther M. K. Wit, Fijs W. B. van Leeuwen, Pim J. van Leeuwen, Henk G. van der Poel

Urology (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Our objective was to assess the diagnostic value of the sentinel node (SN) procedure for lymph node staging in primary intermediate- and high-risk prostate cancer patients with node-negative results on prostate-specific membrane antigen PET/CT (miN0). Methods: From 2016 to 2022, 154 patients with primary, miN0 PCa were retrospectively included. All patients had a Briganti nomogram–assessed nodal risk of more than 5% and underwent a robot-assisted SN procedure for nodal staging. The prevalence of nodal metastases at histopathology and the occurrence of surgical complications according to the Clavien–Dindo classification were evaluated. Results: The SN procedure yielded 84 (14%) tumor-positive lymph nodes with a median metastasis size of 3 mm (interquartile range, 1–4 mm). In total, 55 patients (36%) were reclassified as pN1. A complication of Clavien–Dindo grade 3 or higher occured in 1 patient (0.6%). Conclusion: The SN procedure classified 36% of patients with miN0 prostate cancer with an elevated risk of nodal metastases as pN1.

Original language	English
Pages (from-to)	1563-1566
Number of pages	4
Journal	Journal of nuclear medicine
Volume	64
Issue number	10
DOIs	https://doi.org/10.2967/jnumed.123.265556
Publication status	Published - 2023

Keywords

PSMA PET
lymph node metastases
prostate cancer
sentinel node

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Duin, J. J., de Barros, H. A., Donswijk, M. L., Schaake, E. E., van der Sluis, T. M., Wit, E. M. K., van Leeuwen, F. W. B., van Leeuwen, P. J., & van der Poel, H. G. (2023). The Diagnostic Value of the Sentinel Node Procedure to Detect Occult Lymph Node Metastases in PSMA PET/CT Node–Negative Prostate Cancer Patients. Journal of nuclear medicine, 64(10), 1563-1566. https://doi.org/10.2967/jnumed.123.265556

@article{abd5f432cb174623994c69bf11b605b3,

title = "The Diagnostic Value of the Sentinel Node Procedure to Detect Occult Lymph Node Metastases in PSMA PET/CT Node–Negative Prostate Cancer Patients",

abstract = "Our objective was to assess the diagnostic value of the sentinel node (SN) procedure for lymph node staging in primary intermediate- and high-risk prostate cancer patients with node-negative results on prostate-specific membrane antigen PET/CT (miN0). Methods: From 2016 to 2022, 154 patients with primary, miN0 PCa were retrospectively included. All patients had a Briganti nomogram–assessed nodal risk of more than 5% and underwent a robot-assisted SN procedure for nodal staging. The prevalence of nodal metastases at histopathology and the occurrence of surgical complications according to the Clavien–Dindo classification were evaluated. Results: The SN procedure yielded 84 (14%) tumor-positive lymph nodes with a median metastasis size of 3 mm (interquartile range, 1–4 mm). In total, 55 patients (36%) were reclassified as pN1. A complication of Clavien–Dindo grade 3 or higher occured in 1 patient (0.6%). Conclusion: The SN procedure classified 36% of patients with miN0 prostate cancer with an elevated risk of nodal metastases as pN1.",

keywords = "PSMA PET, lymph node metastases, prostate cancer, sentinel node",

author = "Duin, {Jan J.} and {de Barros}, {Hilda A.} and Donswijk, {Maarten L.} and Schaake, {Eva E.} and {van der Sluis}, {Tim M.} and Wit, {Esther M. K.} and {van Leeuwen}, {Fijs W. B.} and {van Leeuwen}, {Pim J.} and {van der Poel}, {Henk G.}",

note = "Publisher Copyright: COPYRIGHT {\ss} 2023 by the Society of Nuclear Medicine and Molecular Imaging.",

year = "2023",

doi = "https://doi.org/10.2967/jnumed.123.265556",

language = "English",

volume = "64",

pages = "1563--1566",

journal = "Journal of nuclear medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine Inc.",

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Duin, JJ, de Barros, HA, Donswijk, ML, Schaake, EE, van der Sluis, TM, Wit, EMK, van Leeuwen, FWB, van Leeuwen, PJ & van der Poel, HG 2023, 'The Diagnostic Value of the Sentinel Node Procedure to Detect Occult Lymph Node Metastases in PSMA PET/CT Node–Negative Prostate Cancer Patients', Journal of nuclear medicine, vol. 64, no. 10, pp. 1563-1566. https://doi.org/10.2967/jnumed.123.265556

TY - JOUR

T1 - The Diagnostic Value of the Sentinel Node Procedure to Detect Occult Lymph Node Metastases in PSMA PET/CT Node–Negative Prostate Cancer Patients

AU - Duin, Jan J.

AU - de Barros, Hilda A.

AU - Donswijk, Maarten L.

AU - Schaake, Eva E.

AU - van der Sluis, Tim M.

AU - Wit, Esther M. K.

AU - van Leeuwen, Fijs W. B.

AU - van Leeuwen, Pim J.

AU - van der Poel, Henk G.

N1 - Publisher Copyright: COPYRIGHT ß 2023 by the Society of Nuclear Medicine and Molecular Imaging.

PY - 2023

Y1 - 2023

N2 - Our objective was to assess the diagnostic value of the sentinel node (SN) procedure for lymph node staging in primary intermediate- and high-risk prostate cancer patients with node-negative results on prostate-specific membrane antigen PET/CT (miN0). Methods: From 2016 to 2022, 154 patients with primary, miN0 PCa were retrospectively included. All patients had a Briganti nomogram–assessed nodal risk of more than 5% and underwent a robot-assisted SN procedure for nodal staging. The prevalence of nodal metastases at histopathology and the occurrence of surgical complications according to the Clavien–Dindo classification were evaluated. Results: The SN procedure yielded 84 (14%) tumor-positive lymph nodes with a median metastasis size of 3 mm (interquartile range, 1–4 mm). In total, 55 patients (36%) were reclassified as pN1. A complication of Clavien–Dindo grade 3 or higher occured in 1 patient (0.6%). Conclusion: The SN procedure classified 36% of patients with miN0 prostate cancer with an elevated risk of nodal metastases as pN1.

AB - Our objective was to assess the diagnostic value of the sentinel node (SN) procedure for lymph node staging in primary intermediate- and high-risk prostate cancer patients with node-negative results on prostate-specific membrane antigen PET/CT (miN0). Methods: From 2016 to 2022, 154 patients with primary, miN0 PCa were retrospectively included. All patients had a Briganti nomogram–assessed nodal risk of more than 5% and underwent a robot-assisted SN procedure for nodal staging. The prevalence of nodal metastases at histopathology and the occurrence of surgical complications according to the Clavien–Dindo classification were evaluated. Results: The SN procedure yielded 84 (14%) tumor-positive lymph nodes with a median metastasis size of 3 mm (interquartile range, 1–4 mm). In total, 55 patients (36%) were reclassified as pN1. A complication of Clavien–Dindo grade 3 or higher occured in 1 patient (0.6%). Conclusion: The SN procedure classified 36% of patients with miN0 prostate cancer with an elevated risk of nodal metastases as pN1.

KW - PSMA PET

KW - lymph node metastases

KW - prostate cancer

KW - sentinel node

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M3 - Article

C2 - 37414445

SN - 0161-5505

VL - 64

SP - 1563

EP - 1566

JO - Journal of nuclear medicine

JF - Journal of nuclear medicine

IS - 10

ER -

The Diagnostic Value of the Sentinel Node Procedure to Detect Occult Lymph Node Metastases in PSMA PET/CT Node–Negative Prostate Cancer Patients

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Keywords

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