TY - JOUR
T1 - The differential effects of recombinant brain natriuretic peptide, nitroglycerine and dihydralazine on systemic oxygen delivery and gastric mucosal microvascular oxygenation in dogs
AU - Schwarte, L. A.
AU - Schwartges, I.
AU - Scheeren, T. W. L.
AU - Schober, P.
AU - Picker, O.
PY - 2012/5
Y1 - 2012/5
N2 - Brain natriuretic peptide has vasodilatory properties and may thus increase splanchnic perfusion and oxygenation. We compared the effects of recombinant brain natriuretic peptide on gastric mucosal microvascular haemoglobin oxygenation (reflectance spectrophotometry) and systemic variables with those of equi-hypotensive doses of two other vasodilators (nitroglycerine and dihydralazine). Chronically instrumented, healthy dogs were randomly allocated to receive on different days, one of the three drugs (nitroglycerine and dihydralazine doses titrated to reduce mean arterial pressure by ∼20%). Brain natriuretic peptide significantly increased gastric mucosal microvascular haemoglobin oxygenation selectively, i.e. without concomitant haemodynamic effects. In contrast, the other vasodilators either did not increase gastric mucosal microvascular haemoglobin oxygenation at all (nitroglycerine), or did so only with marked increases in other systemic haemodynamic variables (dihydralazine). Our data suggest a potential role of recombinant brain natriuretic peptide selectively for increasing microvascular mucosal oxygenation. Studies are required to extend these findings to the clinical setting. Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.
AB - Brain natriuretic peptide has vasodilatory properties and may thus increase splanchnic perfusion and oxygenation. We compared the effects of recombinant brain natriuretic peptide on gastric mucosal microvascular haemoglobin oxygenation (reflectance spectrophotometry) and systemic variables with those of equi-hypotensive doses of two other vasodilators (nitroglycerine and dihydralazine). Chronically instrumented, healthy dogs were randomly allocated to receive on different days, one of the three drugs (nitroglycerine and dihydralazine doses titrated to reduce mean arterial pressure by ∼20%). Brain natriuretic peptide significantly increased gastric mucosal microvascular haemoglobin oxygenation selectively, i.e. without concomitant haemodynamic effects. In contrast, the other vasodilators either did not increase gastric mucosal microvascular haemoglobin oxygenation at all (nitroglycerine), or did so only with marked increases in other systemic haemodynamic variables (dihydralazine). Our data suggest a potential role of recombinant brain natriuretic peptide selectively for increasing microvascular mucosal oxygenation. Studies are required to extend these findings to the clinical setting. Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84859800201&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/22352680
U2 - https://doi.org/10.1111/j.1365-2044.2011.07047.x
DO - https://doi.org/10.1111/j.1365-2044.2011.07047.x
M3 - Article
C2 - 22352680
SN - 0003-2409
VL - 67
SP - 501
EP - 507
JO - Anaesthesia
JF - Anaesthesia
IS - 5
ER -