TY - JOUR
T1 - The effect of childhood adversity on 4-year outcome in individuals at ultra high risk for psychosis in the Dutch Early Detection Intervention Evaluation (EDIE-NL) Trial
AU - Kraan, T.C.
AU - Ising, H.K.
AU - Fokkema, M.
AU - Velthorst, E.
AU - van den Berg, D.P.G.
AU - Kerkhoven, M.
AU - Veling, W.
AU - Smit, H.F.E.
AU - Linszen, D.H.
AU - Nieman, D.H.
AU - Wunderink, L.
AU - Boonstra, N.
AU - Klaassen, R.M.C.
AU - Dragt, S.
AU - Rietdijk, J.
AU - de Haan, Lieuwe
AU - van der Gaag, M.
PY - 2016
Y1 - 2016
N2 - Childhood adversity is associated with a range of mental disorders, functional impairment and higher health care costs in adulthood. In this study we evaluated if childhood adversity was predictive of adverse clinical and functional outcomes and health care costs in a sample of patients at ultra-high risk (UHR) for developing a psychosis. Structural Equation Modeling was used to examine the effect of childhood adversity on depression, anxiety, transition to psychosis and overall functioning at 4-year follow-up. In addition, we evaluated economic costs of childhood adversity in terms of health care use and productivity loss. Data pertain to 105 UHR participants of the Dutch Early Detection and Intervention Evaluation (EDIE-NL). Physical abuse was associated with higher depression rates (b=0.381, p=0.012) and lower social functional outcome (b=−0.219, p=0.017) at 4-year follow-up. In addition, emotional neglect was negatively associated with social functioning (b=−0.313, p=0.018). We did not find evidence that childhood adversity was associated with transition to psychosis, but the experience of childhood adversity was associated with excess health care costs at follow-up. The data indicate long-term negative effects of childhood adversity on depression, social functioning and health care costs at follow-up in a sample of UHR patients.
AB - Childhood adversity is associated with a range of mental disorders, functional impairment and higher health care costs in adulthood. In this study we evaluated if childhood adversity was predictive of adverse clinical and functional outcomes and health care costs in a sample of patients at ultra-high risk (UHR) for developing a psychosis. Structural Equation Modeling was used to examine the effect of childhood adversity on depression, anxiety, transition to psychosis and overall functioning at 4-year follow-up. In addition, we evaluated economic costs of childhood adversity in terms of health care use and productivity loss. Data pertain to 105 UHR participants of the Dutch Early Detection and Intervention Evaluation (EDIE-NL). Physical abuse was associated with higher depression rates (b=0.381, p=0.012) and lower social functional outcome (b=−0.219, p=0.017) at 4-year follow-up. In addition, emotional neglect was negatively associated with social functioning (b=−0.313, p=0.018). We did not find evidence that childhood adversity was associated with transition to psychosis, but the experience of childhood adversity was associated with excess health care costs at follow-up. The data indicate long-term negative effects of childhood adversity on depression, social functioning and health care costs at follow-up in a sample of UHR patients.
UR - http://www.scopus.com/inward/record.url?scp=84996536209&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.psychres.2016.11.014
DO - https://doi.org/10.1016/j.psychres.2016.11.014
M3 - Article
C2 - 27863320
SN - 0165-1781
VL - 2016
SP - 55
EP - 62
JO - Psychiatry Research
JF - Psychiatry Research
IS - 247
ER -