The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer

Mark van Barele, Chistien C M Buis, Monique M A Brood-van Zanten, H Lena C van Doorn, Katja N Gaarenstroom, Bernadette A M Heemskerk-Gerritsen, Maartje J Hooning, Joanne de Hullu, Marian J Mourits, Curt W Burger

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2 Citations (Scopus)


OBJECTIVE: To compare the effect of tibolone to conjugated estrogens with medroxyprogesterone-acetate (CEE + MPA) on breast density, as a predictor for breast cancer risk, in women with a high risk of breast and ovarian cancer.

METHODS: Women aged 30-50 (N = 114) who had undergone risk-reducing salpingo-oophorectomy (RRSO) were randomized to tibolone or CEE + MPA.

RESULTS: Breast density decreased 46% after RRSO in untreated women, 39% after treatment with tibolone, and 17% after treatment with CEE + MPA; the decrease in breast density after CEE + MPA was significantly different compared with that of untreated women (P = 0.017).

CONCLUSIONS: A decline in breast density is seen after premenopausal RRSO despite the use of both CEE + MPA or tibolone, although lower breast density is seen after tibolone use.

Original languageEnglish
Pages (from-to)1307-1312
Number of pages6
Issue number11
Publication statusPublished - 9 Aug 2021

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