The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer

Mark van Barele; Chistien C M Buis; Monique M A Brood-van Zanten; H Lena C van Doorn; Katja N Gaarenstroom; Bernadette A M Heemskerk-Gerritsen; Maartje J Hooning; Joanne de Hullu; Marian J Mourits; Curt W Burger

doi:https://doi.org/10.1097/GME.0000000000001844

The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer

Mark van Barele, Chistien C M Buis, Monique M A Brood-van Zanten, H Lena C van Doorn, Katja N Gaarenstroom, Bernadette A M Heemskerk-Gerritsen, Maartje J Hooning, Joanne de Hullu, Marian J Mourits, Curt W Burger

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: To compare the effect of tibolone to conjugated estrogens with medroxyprogesterone-acetate (CEE + MPA) on breast density, as a predictor for breast cancer risk, in women with a high risk of breast and ovarian cancer.

METHODS: Women aged 30-50 (N = 114) who had undergone risk-reducing salpingo-oophorectomy (RRSO) were randomized to tibolone or CEE + MPA.

RESULTS: Breast density decreased 46% after RRSO in untreated women, 39% after treatment with tibolone, and 17% after treatment with CEE + MPA; the decrease in breast density after CEE + MPA was significantly different compared with that of untreated women (P = 0.017).

CONCLUSIONS: A decline in breast density is seen after premenopausal RRSO despite the use of both CEE + MPA or tibolone, although lower breast density is seen after tibolone use.

Original language	English
Pages (from-to)	1307-1312
Number of pages	6
Journal	Menopause
Volume	28
Issue number	11
DOIs	https://doi.org/10.1097/GME.0000000000001844
Publication status	Published - 9 Aug 2021

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van Barele, M., Buis, C. C. M., Brood-van Zanten, M. M. A., van Doorn, H. L. C., Gaarenstroom, K. N., Heemskerk-Gerritsen, B. A. M., Hooning, M. J., de Hullu, J., Mourits, M. J., & Burger, C. W. (2021). The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer. Menopause, 28(11), 1307-1312. https://doi.org/10.1097/GME.0000000000001844

@article{a281d999cc5e40509410207809ff0d0e,

title = "The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer",

abstract = "OBJECTIVE: To compare the effect of tibolone to conjugated estrogens with medroxyprogesterone-acetate (CEE + MPA) on breast density, as a predictor for breast cancer risk, in women with a high risk of breast and ovarian cancer.METHODS: Women aged 30-50 (N = 114) who had undergone risk-reducing salpingo-oophorectomy (RRSO) were randomized to tibolone or CEE + MPA.RESULTS: Breast density decreased 46% after RRSO in untreated women, 39% after treatment with tibolone, and 17% after treatment with CEE + MPA; the decrease in breast density after CEE + MPA was significantly different compared with that of untreated women (P = 0.017).CONCLUSIONS: A decline in breast density is seen after premenopausal RRSO despite the use of both CEE + MPA or tibolone, although lower breast density is seen after tibolone use.",

author = "{van Barele}, Mark and Buis, {Chistien C M} and {Brood-van Zanten}, {Monique M A} and {van Doorn}, {H Lena C} and Gaarenstroom, {Katja N} and Heemskerk-Gerritsen, {Bernadette A M} and Hooning, {Maartje J} and {de Hullu}, Joanne and Mourits, {Marian J} and Burger, {Curt W}",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 by The North American Menopause Society.",

year = "2021",

month = aug,

day = "9",

doi = "https://doi.org/10.1097/GME.0000000000001844",

language = "English",

volume = "28",

pages = "1307--1312",

journal = "Menopause",

issn = "1072-3714",

publisher = "Lippincott Williams and Wilkins",

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van Barele, M, Buis, CCM, Brood-van Zanten, MMA, van Doorn, HLC, Gaarenstroom, KN, Heemskerk-Gerritsen, BAM, Hooning, MJ, de Hullu, J, Mourits, MJ & Burger, CW 2021, 'The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer', Menopause, vol. 28, no. 11, pp. 1307-1312. https://doi.org/10.1097/GME.0000000000001844

The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer. / van Barele, Mark; Buis, Chistien C M; Brood-van Zanten, Monique M A et al.
In: Menopause, Vol. 28, No. 11, 09.08.2021, p. 1307-1312.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer

AU - van Barele, Mark

AU - Buis, Chistien C M

AU - Brood-van Zanten, Monique M A

AU - van Doorn, H Lena C

AU - Gaarenstroom, Katja N

AU - Heemskerk-Gerritsen, Bernadette A M

AU - Hooning, Maartje J

AU - de Hullu, Joanne

AU - Mourits, Marian J

AU - Burger, Curt W

PY - 2021/8/9

Y1 - 2021/8/9

N2 - OBJECTIVE: To compare the effect of tibolone to conjugated estrogens with medroxyprogesterone-acetate (CEE + MPA) on breast density, as a predictor for breast cancer risk, in women with a high risk of breast and ovarian cancer.METHODS: Women aged 30-50 (N = 114) who had undergone risk-reducing salpingo-oophorectomy (RRSO) were randomized to tibolone or CEE + MPA.RESULTS: Breast density decreased 46% after RRSO in untreated women, 39% after treatment with tibolone, and 17% after treatment with CEE + MPA; the decrease in breast density after CEE + MPA was significantly different compared with that of untreated women (P = 0.017).CONCLUSIONS: A decline in breast density is seen after premenopausal RRSO despite the use of both CEE + MPA or tibolone, although lower breast density is seen after tibolone use.

AB - OBJECTIVE: To compare the effect of tibolone to conjugated estrogens with medroxyprogesterone-acetate (CEE + MPA) on breast density, as a predictor for breast cancer risk, in women with a high risk of breast and ovarian cancer.METHODS: Women aged 30-50 (N = 114) who had undergone risk-reducing salpingo-oophorectomy (RRSO) were randomized to tibolone or CEE + MPA.RESULTS: Breast density decreased 46% after RRSO in untreated women, 39% after treatment with tibolone, and 17% after treatment with CEE + MPA; the decrease in breast density after CEE + MPA was significantly different compared with that of untreated women (P = 0.017).CONCLUSIONS: A decline in breast density is seen after premenopausal RRSO despite the use of both CEE + MPA or tibolone, although lower breast density is seen after tibolone use.

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DO - https://doi.org/10.1097/GME.0000000000001844

M3 - Article

C2 - 34374687

SN - 1072-3714

VL - 28

SP - 1307

EP - 1312

JO - Menopause

JF - Menopause

IS - 11

ER -

The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer

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