The effect of intrathecal baclofen treatment on activities of daily life in children and young adults with cerebral palsy and progressive neurological disorders

Laura Bonouvrie; Jules Becher; Dan Soudant; Annemieke Buizer; Willem van Ouwerkerk; Georges Vles; R. Jeroen Vermeulen

doi:https://doi.org/10.1016/j.ejpn.2016.02.013

The effect of intrathecal baclofen treatment on activities of daily life in children and young adults with cerebral palsy and progressive neurological disorders

Laura Bonouvrie, Jules Becher, Dan Soudant, Annemieke Buizer, Willem van Ouwerkerk, Georges Vles, R. Jeroen Vermeulen

Research output: Contribution to journal › Article › Academic › peer-review

23 Citations (Scopus)

Abstract

Introduction
Intrathecal baclofen (ITB) treatment is applied in patients with spastic cerebral palsy (SCP), dystonic cerebral palsy (DCP) and progressive neurological disease (PND). Our aim was to investigate whether ITB treatment has a different effect on activities of daily life (ADL) in these groups.

Method
A retrospective and cross-sectional survey was conducted using a questionnaire to assess the qualitative effect of ITB (Likert scale) on different domains of functioning (mobility, personal care, communication, comfort) and satisfaction with the results. Groups were compared using non-parametric statistics.

Results
Questionnaires were completed for 68 patients (39 SCP, 13 DCP, 16 PND). Satisfaction scores were relatively high in all groups (7–8) and the positive effect on personal care and communication was similar in all groups. The PND group had the shortest follow-up and scored significantly less favourably for the effect on mobility and comfort.

Discussion
This is the first study to show that ITB treatment has similar effects on personal care and communication in stable and progressive neurological disease. The decrease in mobility in the PND group is likely due to the progressive nature of the disease. The different effect on comfort between groups is mainly due to the smaller effect on startles in the PND group.

Original language	English
Pages (from-to)	538-544
Journal	European Journal of Paediatric Neurology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/j.ejpn.2016.02.013
Publication status	Published - Jul 2016

Keywords

Baclofen
Cerebral palsy
Child
Dystonia
Muscle spasticity
Nervous system diseases

Access to Document

https://doi.org/10.1016/j.ejpn.2016.02.013

Cite this

Bonouvrie, L., Becher, J., Soudant, D., Buizer, A., van Ouwerkerk, W., Vles, G., & Vermeulen, R. J. (2016). The effect of intrathecal baclofen treatment on activities of daily life in children and young adults with cerebral palsy and progressive neurological disorders. European Journal of Paediatric Neurology, 20(4), 538-544. https://doi.org/10.1016/j.ejpn.2016.02.013

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title = "The effect of intrathecal baclofen treatment on activities of daily life in children and young adults with cerebral palsy and progressive neurological disorders",

abstract = "IntroductionIntrathecal baclofen (ITB) treatment is applied in patients with spastic cerebral palsy (SCP), dystonic cerebral palsy (DCP) and progressive neurological disease (PND). Our aim was to investigate whether ITB treatment has a different effect on activities of daily life (ADL) in these groups.MethodA retrospective and cross-sectional survey was conducted using a questionnaire to assess the qualitative effect of ITB (Likert scale) on different domains of functioning (mobility, personal care, communication, comfort) and satisfaction with the results. Groups were compared using non-parametric statistics.ResultsQuestionnaires were completed for 68 patients (39 SCP, 13 DCP, 16 PND). Satisfaction scores were relatively high in all groups (7–8) and the positive effect on personal care and communication was similar in all groups. The PND group had the shortest follow-up and scored significantly less favourably for the effect on mobility and comfort.DiscussionThis is the first study to show that ITB treatment has similar effects on personal care and communication in stable and progressive neurological disease. The decrease in mobility in the PND group is likely due to the progressive nature of the disease. The different effect on comfort between groups is mainly due to the smaller effect on startles in the PND group.",

keywords = "Baclofen, Cerebral palsy, Child, Dystonia, Muscle spasticity, Nervous system diseases",

author = "Laura Bonouvrie and Jules Becher and Dan Soudant and Annemieke Buizer and {van Ouwerkerk}, Willem and Georges Vles and Vermeulen, {R. Jeroen}",

year = "2016",

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doi = "https://doi.org/10.1016/j.ejpn.2016.02.013",

language = "English",

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pages = "538--544",

journal = "European Journal of Paediatric Neurology",

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Bonouvrie, L, Becher, J, Soudant, D, Buizer, A, van Ouwerkerk, W, Vles, G & Vermeulen, RJ 2016, 'The effect of intrathecal baclofen treatment on activities of daily life in children and young adults with cerebral palsy and progressive neurological disorders', European Journal of Paediatric Neurology, vol. 20, no. 4, pp. 538-544. https://doi.org/10.1016/j.ejpn.2016.02.013

The effect of intrathecal baclofen treatment on activities of daily life in children and young adults with cerebral palsy and progressive neurological disorders. / Bonouvrie, Laura; Becher, Jules; Soudant, Dan et al.
In: European Journal of Paediatric Neurology, Vol. 20, No. 4, 07.2016, p. 538-544.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The effect of intrathecal baclofen treatment on activities of daily life in children and young adults with cerebral palsy and progressive neurological disorders

AU - Bonouvrie, Laura

AU - Becher, Jules

AU - Soudant, Dan

AU - Buizer, Annemieke

AU - van Ouwerkerk, Willem

AU - Vles, Georges

AU - Vermeulen, R. Jeroen

PY - 2016/7

Y1 - 2016/7

N2 - IntroductionIntrathecal baclofen (ITB) treatment is applied in patients with spastic cerebral palsy (SCP), dystonic cerebral palsy (DCP) and progressive neurological disease (PND). Our aim was to investigate whether ITB treatment has a different effect on activities of daily life (ADL) in these groups.MethodA retrospective and cross-sectional survey was conducted using a questionnaire to assess the qualitative effect of ITB (Likert scale) on different domains of functioning (mobility, personal care, communication, comfort) and satisfaction with the results. Groups were compared using non-parametric statistics.ResultsQuestionnaires were completed for 68 patients (39 SCP, 13 DCP, 16 PND). Satisfaction scores were relatively high in all groups (7–8) and the positive effect on personal care and communication was similar in all groups. The PND group had the shortest follow-up and scored significantly less favourably for the effect on mobility and comfort.DiscussionThis is the first study to show that ITB treatment has similar effects on personal care and communication in stable and progressive neurological disease. The decrease in mobility in the PND group is likely due to the progressive nature of the disease. The different effect on comfort between groups is mainly due to the smaller effect on startles in the PND group.

AB - IntroductionIntrathecal baclofen (ITB) treatment is applied in patients with spastic cerebral palsy (SCP), dystonic cerebral palsy (DCP) and progressive neurological disease (PND). Our aim was to investigate whether ITB treatment has a different effect on activities of daily life (ADL) in these groups.MethodA retrospective and cross-sectional survey was conducted using a questionnaire to assess the qualitative effect of ITB (Likert scale) on different domains of functioning (mobility, personal care, communication, comfort) and satisfaction with the results. Groups were compared using non-parametric statistics.ResultsQuestionnaires were completed for 68 patients (39 SCP, 13 DCP, 16 PND). Satisfaction scores were relatively high in all groups (7–8) and the positive effect on personal care and communication was similar in all groups. The PND group had the shortest follow-up and scored significantly less favourably for the effect on mobility and comfort.DiscussionThis is the first study to show that ITB treatment has similar effects on personal care and communication in stable and progressive neurological disease. The decrease in mobility in the PND group is likely due to the progressive nature of the disease. The different effect on comfort between groups is mainly due to the smaller effect on startles in the PND group.

KW - Baclofen

KW - Cerebral palsy

KW - Child

KW - Dystonia

KW - Muscle spasticity

KW - Nervous system diseases

U2 - https://doi.org/10.1016/j.ejpn.2016.02.013

DO - https://doi.org/10.1016/j.ejpn.2016.02.013

M3 - Article

C2 - 26995704

SN - 1090-3798

VL - 20

SP - 538

EP - 544

JO - European Journal of Paediatric Neurology

JF - European Journal of Paediatric Neurology

IS - 4

ER -