TY - JOUR
T1 - The effect of oxandrolone on voice frequency in growth hormone-treated girls with turner syndrome
AU - Menke, Leonie A.
AU - Sas, Theo C.J.
AU - Van Koningsbrugge, Sophie H.L.
AU - De Ridder, Maria A.J.
AU - Zandwijken, Gladys R.J.
AU - Boersma, Bart
AU - Dejonckere, Philippe H.
AU - De Muinck Keizer-Schrama, Sabine M.P.F.
AU - Otten, Barto J.
AU - Wit, Jan M.
PY - 2011/9
Y1 - 2011/9
N2 - Objectives/Hypothesis: Oxandrolone (Ox) increases height gain but may also cause voice deepening in growth hormone (GH)-treated girls with Turner syndrome (TS). We assessed the effect of Ox on objective and subjective speaking voice frequency in GH-treated girls with TS. Study Design: A multicenter, randomized, placebo (Pl)-controlled, double-blind study was conducted. Methods: One hundred thirty-three patients were included and treated with GH (1.33 mg/m 2/d) from baseline, combined with Pl or Ox in a low (0.03 mg/kg/d) or conventional (0.06 mg/kg/d) dose from the age of 8 years and estrogens from the age of 12 years. Yearly from starting Ox/Pl until 6 months after discontinuing GH + Ox/Pl, voices were recorded and questionnaires were completed. Results: At start, mean (±standard deviation [SD]) voice frequency SD score (SDS) was high for age (1.0 ± 1.2, P < 0.001) but normal for height. Compared with GH + Pl, voices tended to lower on GH + Ox 0.03 (P = 0.09) and significantly lowered on GH + Ox 0.06 (P = 0.007). At the last measurement, voice frequency SDS was still relatively high in GH + Pl group (0.6 ± 0.7, P = 0.002) but similar to healthy girls in both GH + Ox groups. Voice frequency became lower than -2 SDS in one patient (3%) on GH + Ox 0.03 and three patients (11%) on GH + Ox 0.06. The percentage of patients reporting subjective voice deepening was similar between the dosage groups. Conclusions: Untreated girls with TS have relatively high-pitched voices. The addition of Ox to GH decreases voice frequency in a dose-dependent way. Although most voice frequencies remain within the normal range, they may occasionally become lower than -2 SDS, especially on GH + Ox 0.06 mg/kg/d.
AB - Objectives/Hypothesis: Oxandrolone (Ox) increases height gain but may also cause voice deepening in growth hormone (GH)-treated girls with Turner syndrome (TS). We assessed the effect of Ox on objective and subjective speaking voice frequency in GH-treated girls with TS. Study Design: A multicenter, randomized, placebo (Pl)-controlled, double-blind study was conducted. Methods: One hundred thirty-three patients were included and treated with GH (1.33 mg/m 2/d) from baseline, combined with Pl or Ox in a low (0.03 mg/kg/d) or conventional (0.06 mg/kg/d) dose from the age of 8 years and estrogens from the age of 12 years. Yearly from starting Ox/Pl until 6 months after discontinuing GH + Ox/Pl, voices were recorded and questionnaires were completed. Results: At start, mean (±standard deviation [SD]) voice frequency SD score (SDS) was high for age (1.0 ± 1.2, P < 0.001) but normal for height. Compared with GH + Pl, voices tended to lower on GH + Ox 0.03 (P = 0.09) and significantly lowered on GH + Ox 0.06 (P = 0.007). At the last measurement, voice frequency SDS was still relatively high in GH + Pl group (0.6 ± 0.7, P = 0.002) but similar to healthy girls in both GH + Ox groups. Voice frequency became lower than -2 SDS in one patient (3%) on GH + Ox 0.03 and three patients (11%) on GH + Ox 0.06. The percentage of patients reporting subjective voice deepening was similar between the dosage groups. Conclusions: Untreated girls with TS have relatively high-pitched voices. The addition of Ox to GH decreases voice frequency in a dose-dependent way. Although most voice frequencies remain within the normal range, they may occasionally become lower than -2 SDS, especially on GH + Ox 0.06 mg/kg/d.
KW - Estrogen replacement therapy
KW - Growth hormone therapy
KW - Oxandrolone
KW - Turner syndrome
KW - Voice
UR - http://www.scopus.com/inward/record.url?scp=80052325732&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jvoice.2010.06.002
DO - https://doi.org/10.1016/j.jvoice.2010.06.002
M3 - Article
C2 - 20971614
SN - 0892-1997
VL - 25
SP - 602
EP - 610
JO - Journal of voice
JF - Journal of voice
IS - 5
ER -