The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: a randomized, controlled trial

Jannique G Z van Uffelen, Marijke J M Chin A Paw, Marijke Hopman-Rock, Willem van Mechelen

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48 Citations (Scopus)


OBJECTIVES: To examine the effect of walking and vitamin B supplementation on quality-of-life (QoL) in community-dwelling adults with mild cognitive impairment.

METHODS: One year, double-blind, placebo-controlled trial. Participants were randomized to: (1) twice-weekly, group-based, moderate-intensity walking program (n = 77) or a light-intensity placebo activity program (n = 75); and (2) daily vitamin B pills containing 5 mg folic acid, 0.4 mg B12, 50 mg B6 (n = 78) or placebo pills (n = 74). QoL was measured at baseline, after six and 12 months using the population-specific Dementia Quality-of-Life (D-QoL) to assess overall QoL and the generic Short-Form 12 mental and physical component scales (SF12-MCS and SF12-PCS) to assess health-related QoL.

RESULTS: Baseline levels of QoL were relatively high. Modified intention-to-treat analyses revealed no positive main intervention effect of walking or vitamin supplementation. In both men and women, ratings of D-QoL-belonging and D-QoL-positive affect subscales improved with 0.003 (P = 0.04) and 0.002 points (P = 0.06) with each percent increase in attendance to the walking program. Only in men, SF12-MCS increased with 0.03 points with each percent increase in attendance (P = 0.08).

CONCLUSION: Several small but significant improvements in QoL were observed with increasing attendance to the walking program. No effect of vitamin B supplementation was observed.

TRIAL REGISTRATION: International Standard Randomized Controlled Trial Number Register, 19227688,

Original languageEnglish
Pages (from-to)1137-46
Number of pages10
JournalQuality of life research
Issue number7
Publication statusPublished - Sept 2007


  • Aged
  • Aged, 80 and over
  • Cognition
  • Cognition Disorders/drug therapy
  • Community Health Services
  • Dementia/drug therapy
  • Dietary Supplements
  • Female
  • Health Surveys
  • Humans
  • Interviews as Topic
  • Male
  • Neuropsychological Tests
  • Nutritional Status
  • Program Evaluation
  • Psychometrics
  • Quality of Life
  • Residence Characteristics
  • Surveys and Questionnaires
  • Treatment Outcome
  • Vitamin B Complex/therapeutic use
  • Walking

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