TY - JOUR
T1 - The effects of ECT on cognitive functioning in the elderly
T2 - A review
AU - Tielkes, Caroline E.M.
AU - Comijs, Hannie C.
AU - Verwijk, Esmée
AU - Stek, Max L.
PY - 2008/8/1
Y1 - 2008/8/1
N2 - Background: Electroconvulsive therapy (ECT) as a single course or in maintenance form (M-ECT) is an effective treatment in depressed elderly. However, ECT may have adverse effects on cognition. Objective: To review all studies from 1980-2006 on ECT and cognition in the elderly with a minimum age of 55 years or a mean age of 55 years, and with valid measurements of cognition before and after ECT. Results: Nine out of the 15 eligible studies were focused exclusively on the elderly. Three studies reported verbal learning- and recall problems post ECT, while three studies found positive effects of ECT on memory, speed of processing and concentration. Global cognitive functioning in patients with cognitive impairment improved in all studies. At follow up, most studies reported improvement of cognitive functions. Learning verbal information and executive functioning were impaired in M-ECT patients whereas global cognition remained stable after M-ECT over a year. Conclusions: To date research of ECT on cognitive functioning in the elderly is very limited. Small sample size, lack of controls, use of a single screening instrument and a short follow up period may explain the conflicting results. Given the clinical importance, more extensive research on cognition in elderly treated with ECT is urgently needed.
AB - Background: Electroconvulsive therapy (ECT) as a single course or in maintenance form (M-ECT) is an effective treatment in depressed elderly. However, ECT may have adverse effects on cognition. Objective: To review all studies from 1980-2006 on ECT and cognition in the elderly with a minimum age of 55 years or a mean age of 55 years, and with valid measurements of cognition before and after ECT. Results: Nine out of the 15 eligible studies were focused exclusively on the elderly. Three studies reported verbal learning- and recall problems post ECT, while three studies found positive effects of ECT on memory, speed of processing and concentration. Global cognitive functioning in patients with cognitive impairment improved in all studies. At follow up, most studies reported improvement of cognitive functions. Learning verbal information and executive functioning were impaired in M-ECT patients whereas global cognition remained stable after M-ECT over a year. Conclusions: To date research of ECT on cognitive functioning in the elderly is very limited. Small sample size, lack of controls, use of a single screening instrument and a short follow up period may explain the conflicting results. Given the clinical importance, more extensive research on cognition in elderly treated with ECT is urgently needed.
KW - Cognition
KW - Depression
KW - Elderly
KW - Electroconvulsive therapy
UR - http://www.scopus.com/inward/record.url?scp=50249144462&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=50249144462&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/18311845
U2 - https://doi.org/10.1002/gps.1989
DO - https://doi.org/10.1002/gps.1989
M3 - Review article
C2 - 18311845
SN - 0885-6230
VL - 23
SP - 789
EP - 795
JO - International journal of geriatric psychiatry
JF - International journal of geriatric psychiatry
IS - 8
ER -