TY - JOUR
T1 - The efficacy of standard laxative use for the prevention and treatment of opioid induced constipation during oxycodone use: a small Dutch observational pilot study
AU - Koopmans-Klein, Gineke
AU - Wagemans, Michel F. M.
AU - Wartenberg, Hans C. H.
AU - van Megen, Yvonne J. B.
AU - Huygen, Frank J. P. M.
PY - 2016
Y1 - 2016
N2 - Dutch clinical guidelines recommend that a standard laxative treatment (SLT) should be prescribed concomitantly when starting opioid treatment to prevent opioid-induced constipation (OIC). Clinical evidence for SLT in the treatment of OIC is lacking, therefore an observational pilot study was performed to explore the efficacy and tolerability of SLT on OIC in patients treated with the opioid oxycodone. Twenty-four patients (58% female, median (range) age 65 (39-92)) were included in this pilot study. The analysis showed that 9 out of 21 patients (43%) were non-responders to SLT. When also taking into consideration patients tending to develop diarrhea 75% of patients are non-responsive to SLT. This pilot study indicates that optimal laxative therapy (SLT) might not be effective and feasible for the prevention and treatment of OIC
AB - Dutch clinical guidelines recommend that a standard laxative treatment (SLT) should be prescribed concomitantly when starting opioid treatment to prevent opioid-induced constipation (OIC). Clinical evidence for SLT in the treatment of OIC is lacking, therefore an observational pilot study was performed to explore the efficacy and tolerability of SLT on OIC in patients treated with the opioid oxycodone. Twenty-four patients (58% female, median (range) age 65 (39-92)) were included in this pilot study. The analysis showed that 9 out of 21 patients (43%) were non-responders to SLT. When also taking into consideration patients tending to develop diarrhea 75% of patients are non-responsive to SLT. This pilot study indicates that optimal laxative therapy (SLT) might not be effective and feasible for the prevention and treatment of OIC
U2 - https://doi.org/10.1586/17474124.2016.1129275
DO - https://doi.org/10.1586/17474124.2016.1129275
M3 - Article
C2 - 26641540
SN - 1747-4132
VL - 10
SP - 547
EP - 553
JO - Expert review of gastroenterology & hepatology
JF - Expert review of gastroenterology & hepatology
IS - 4
ER -