TY - JOUR
T1 - The endothelial glycocalyx protects against myocardial edema
AU - van den Berg, Bernard M.
AU - Vink, Hans
AU - Spaan, Jos A. E.
PY - 2003
Y1 - 2003
N2 - Myocardial tissue edema attributable to increased microvascular fluid loss contributes to cardiac dysfunction after myocardial ischemia, cardiopulmonary bypass, hypertension, and sepsis. Recent studies suggest that carbohydrate structures on the luminal surface of microvascular endothelium are essential to prevent tissue edema. We carefully preserved these structures for visualization with electron microscopy, revealing that the rat myocardial capillary endothelial surface is coated with a 0.2- to 0.5-mum-thick carbohydrate layer and that its degradation instantly results in notable myocardial tissue edema
AB - Myocardial tissue edema attributable to increased microvascular fluid loss contributes to cardiac dysfunction after myocardial ischemia, cardiopulmonary bypass, hypertension, and sepsis. Recent studies suggest that carbohydrate structures on the luminal surface of microvascular endothelium are essential to prevent tissue edema. We carefully preserved these structures for visualization with electron microscopy, revealing that the rat myocardial capillary endothelial surface is coated with a 0.2- to 0.5-mum-thick carbohydrate layer and that its degradation instantly results in notable myocardial tissue edema
U2 - https://doi.org/10.1161/01.RES.0000065917.53950.75
DO - https://doi.org/10.1161/01.RES.0000065917.53950.75
M3 - Editorial
C2 - 12637366
SN - 0009-7330
VL - 92
SP - 592
EP - 594
JO - Circulation Research
JF - Circulation Research
IS - 6
ER -