TY - JOUR
T1 - The essential role of recurrent processing for figure-ground perception in mice
AU - Kirchberger, L.
AU - Mukherjee, S.
AU - Schnabel, U.H.
AU - van Beest, E.H.
AU - Barsegyan, A.
AU - Levelt, C.N.
AU - Alexander Heimel, J.
AU - Lorteije, J.A.M.
AU - van der Togt, C.
AU - Self, M.W.
AU - Roelfsema, P.R.
N1 - Funding Information: The work was supported by NWO (ALW grant 823-02-010) and the European Union?s Horizon 2020 and FP7 Research and Innovation Program (grant agreements 720270 and 785907 ?Human Brain Project SGA1 and SGA2?, ERC grant agreement 339490 ?Cortic_al_ gorithms,? FLAG-ERA JTC grant ChampMouse and the Erasmus Mundus ?NeuroTime? program) and the Friends Foundation of the Netherlands Institute for Neuroscience. Publisher Copyright: Copyright © 2021 The Authors, some rights reserved.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Copyright © 2021 The Authors, some rights reserved.The segregation of figures from the background is an important step in visual perception. In primary visual cortex, figures evoke stronger activity than backgrounds during a delayed phase of the neuronal responses, but it is unknown how this figure-ground modulation (FGM) arises and whether it is necessary for perception. Here, we show, using optogenetic silencing in mice, that the delayed V1 response phase is necessary for figure-ground segregation. Neurons in higher visual areas also exhibit FGM and optogenetic silencing of higher areas reduced FGM in V1. In V1, figures elicited higher activity of vasoactive intestinal peptide–expressing (VIP) interneurons than the background, whereas figures suppressed somatostatin-positive interneurons, resulting in an increased activation of pyramidal cells. Optogenetic silencing of VIP neurons reduced FGM in V1, indicating that disinhibitory circuits contribute to FGM. Our results provide insight into how lower and higher areas of the visual cortex interact to shape visual perception.
AB - Copyright © 2021 The Authors, some rights reserved.The segregation of figures from the background is an important step in visual perception. In primary visual cortex, figures evoke stronger activity than backgrounds during a delayed phase of the neuronal responses, but it is unknown how this figure-ground modulation (FGM) arises and whether it is necessary for perception. Here, we show, using optogenetic silencing in mice, that the delayed V1 response phase is necessary for figure-ground segregation. Neurons in higher visual areas also exhibit FGM and optogenetic silencing of higher areas reduced FGM in V1. In V1, figures elicited higher activity of vasoactive intestinal peptide–expressing (VIP) interneurons than the background, whereas figures suppressed somatostatin-positive interneurons, resulting in an increased activation of pyramidal cells. Optogenetic silencing of VIP neurons reduced FGM in V1, indicating that disinhibitory circuits contribute to FGM. Our results provide insight into how lower and higher areas of the visual cortex interact to shape visual perception.
UR - http://www.scopus.com/inward/record.url?scp=85109031575&partnerID=8YFLogxK
UR - https://pure.uva.nl/ws/files/74207732/Supplementary_Materials_The_essential_role_of_recurrent_processing_for_figure_ground_perception_in_mice.pdf
U2 - https://doi.org/10.1126/sciadv.abe1833
DO - https://doi.org/10.1126/sciadv.abe1833
M3 - Article
C2 - 34193411
SN - 2375-2548
VL - 7
JO - Science advances
JF - Science advances
IS - 27
M1 - eabe1833
ER -