TY - JOUR
T1 - The evolving role of radiotherapy in the management of small cell lung cancer
AU - Mishra, Mark V.
AU - Louie, Alexander V.
AU - Gondi, Vinai
AU - Slotman, Ben
PY - 2018
Y1 - 2018
N2 - Small cell lung cancer (SCLC) represents a small but significant subset of newly diagnosed lung cancers. In spite of being both chemo- and radiation-sensitive, SCLC has a high-propensity for recurrence after treatment. Although systemic therapy plays a central role in the management of patients with SCLC, many of the advances in overall survival for patients with SCLC have directly related to the use of radiation therapy. The objective of this review is to discuss the key radiation therapy clinical trials that have defined the current standard-of-care treatment for SCLC, and to review ongoing advances in radiation therapy that may further advance outcomes for patients with SCLC.
AB - Small cell lung cancer (SCLC) represents a small but significant subset of newly diagnosed lung cancers. In spite of being both chemo- and radiation-sensitive, SCLC has a high-propensity for recurrence after treatment. Although systemic therapy plays a central role in the management of patients with SCLC, many of the advances in overall survival for patients with SCLC have directly related to the use of radiation therapy. The objective of this review is to discuss the key radiation therapy clinical trials that have defined the current standard-of-care treatment for SCLC, and to review ongoing advances in radiation therapy that may further advance outcomes for patients with SCLC.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85051256138&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30206498
U2 - https://doi.org/10.21037/jtd.2018.06.98
DO - https://doi.org/10.21037/jtd.2018.06.98
M3 - Review article
C2 - 30206498
SN - 2072-1439
VL - 10
SP - S2545-S2554
JO - Journal of thoracic disease
JF - Journal of thoracic disease
ER -