TY - JOUR
T1 - The Expanding Therapeutic Armamentarium for Inflammatory Bowel Disease: How to Choose the Right Drug[s] for Our Patients?
AU - Hindryckx, Pieter
AU - Vande Casteele, Niels
AU - Novak, Gregor
AU - Khanna, Reena
AU - D'Haens, Geert
AU - Sandborn, William J.
AU - Danese, Silvio
AU - Jairath, Vipul
AU - Feagan, Brian G.
PY - 2018
Y1 - 2018
N2 - The therapeutic landscape for inflammatory bowel disease [IBD] is rapidly evolving. Two new biologic drugs, vedolizumab and ustekinumab, have recently entered the marketplace, the first biosimilars have been introduced, and several other agents are at an advanced stage of clinical development. In parallel, therapeutic goals have shifted from symptom control towards mucosal healing and prevention of bowel damage. In the coming years, gastroenterologists will be faced with unprecedented choices when selecting the best treatment for their patients with IBD. In this article, we review existing data on the mechanisms of action, efficacy, and safety of recently approved and late-stage pipeline therapies, and use this information to speculate on the positioning of these drugs, alone or in combination, in therapeutic algorithms for Crohn's disease and ulcerative colitis
AB - The therapeutic landscape for inflammatory bowel disease [IBD] is rapidly evolving. Two new biologic drugs, vedolizumab and ustekinumab, have recently entered the marketplace, the first biosimilars have been introduced, and several other agents are at an advanced stage of clinical development. In parallel, therapeutic goals have shifted from symptom control towards mucosal healing and prevention of bowel damage. In the coming years, gastroenterologists will be faced with unprecedented choices when selecting the best treatment for their patients with IBD. In this article, we review existing data on the mechanisms of action, efficacy, and safety of recently approved and late-stage pipeline therapies, and use this information to speculate on the positioning of these drugs, alone or in combination, in therapeutic algorithms for Crohn's disease and ulcerative colitis
U2 - https://doi.org/10.1093/ecco-jcc/jjx117
DO - https://doi.org/10.1093/ecco-jcc/jjx117
M3 - Review article
C2 - 28961959
SN - 1873-9946
VL - 12
SP - 105
EP - 119
JO - Journal of Crohn s & colitis
JF - Journal of Crohn s & colitis
IS - 1
ER -