The first multicentre study on coronary anomalies in the Netherlands: MuSCAT

C. J. Koppel; B. W. Driesen; R. J. de Winter; A. E. van den Bosch; R. van Kimmenade; L. J. Wagenaar; J. W. Jukema; M. G. Hazekamp; F. van der Kley; M. R. M. Jongbloed; P. Kiès; A. D. Egorova; D. B. H. Verheijen; P. Damman; P. H. Schoof; J. Wilschut; M. Stoel; R. G. H. Speekenbrink; M. Voskuil; H. W. Vliegen

doi:https://doi.org/10.1007/s12471-021-01556-9

The first multicentre study on coronary anomalies in the Netherlands: MuSCAT

C. J. Koppel, B. W. Driesen, R. J. de Winter, A. E. van den Bosch, R. van Kimmenade, L. J. Wagenaar, J. W. Jukema, M. G. Hazekamp, F. van der Kley, M. R. M. Jongbloed, P. Kiès, A. D. Egorova, D. B. H. Verheijen, P. Damman, P. H. Schoof, J. Wilschut, M. Stoel, R. G. H. Speekenbrink, M. Voskuil, H. W. Vliegen

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Abstract

Background: Current guidelines on coronary anomalies are primarily based on expert consensus and a limited number of trials. A gold standard for diagnosis and a consensus on the treatment strategy in this patient group are lacking, especially for patients with an anomalous origin of a coronary artery from the opposite sinus of Valsalva (ACAOS) with an interarterial course. Aim: To provide evidence-substantiated recommendations for diagnostic work-up, treatment and follow-up of patients with anomalous coronary arteries. Methods: A clinical care pathway for patients with ACAOS was established by six Dutch centres. Prospectively included patients undergo work-up according to protocol using computed tomography (CT) angiography, ischaemia detection, echocardiography and coronary angiography with intracoronary measurements to assess anatomical and physiological characteristics of the ACAOS. Surgical and functional follow-up results are evaluated by CT angiography, ischaemia detection and a quality-of-life questionnaire. Patient inclusion for the first multicentre study on coronary anomalies in the Netherlands started in 2020 and will continue for at least 3 years with a minimum of 2 years of follow-up. For patients with a right or left coronary artery originating from the pulmonary artery and coronary arteriovenous fistulas a registry is maintained. Results: Primary outcomes are: (cardiac) death, myocardial ischaemia attributable to the ACAOS, re-intervention after surgery and intervention after initially conservative treatment. The influence of work-up examinations on treatment choice is also evaluated. Conclusions: Structural evidence for the appropriate management of patients with coronary anomalies, especially (interarterial) ACAOS, is lacking. By means of a structured care pathway in a multicentre setting, we aim to provide an evidence-based strategy for the diagnostic evaluation and treatment of this patient group.

Original language	English
Pages (from-to)	311-317
Number of pages	7
Journal	Netherlands heart journal
Volume	29
Issue number	6
DOIs	https://doi.org/10.1007/s12471-021-01556-9
Publication status	Published - 1 Jun 2021

Keywords

Anomalous coronary artery from the opposite sinus of Valsalva
Anomalous coronary artery from the pulmonary artery
Coronary anomalies
Coronary arteriovenous fistula
Multicentre study

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Koppel, C. J., Driesen, B. W., de Winter, R. J., van den Bosch, A. E., van Kimmenade, R., Wagenaar, L. J., Jukema, J. W., Hazekamp, M. G., van der Kley, F., Jongbloed, M. R. M., Kiès, P., Egorova, A. D., Verheijen, D. B. H., Damman, P., Schoof, P. H., Wilschut, J., Stoel, M., Speekenbrink, R. G. H., Voskuil, M., & Vliegen, H. W. (2021). The first multicentre study on coronary anomalies in the Netherlands: MuSCAT. Netherlands heart journal, 29(6), 311-317. https://doi.org/10.1007/s12471-021-01556-9

@article{36ebed4ad80546fa97df32575fc73135,

title = "The first multicentre study on coronary anomalies in the Netherlands: MuSCAT",

abstract = "Background: Current guidelines on coronary anomalies are primarily based on expert consensus and a limited number of trials. A gold standard for diagnosis and a consensus on the treatment strategy in this patient group are lacking, especially for patients with an anomalous origin of a coronary artery from the opposite sinus of Valsalva (ACAOS) with an interarterial course. Aim: To provide evidence-substantiated recommendations for diagnostic work-up, treatment and follow-up of patients with anomalous coronary arteries. Methods: A clinical care pathway for patients with ACAOS was established by six Dutch centres. Prospectively included patients undergo work-up according to protocol using computed tomography (CT) angiography, ischaemia detection, echocardiography and coronary angiography with intracoronary measurements to assess anatomical and physiological characteristics of the ACAOS. Surgical and functional follow-up results are evaluated by CT angiography, ischaemia detection and a quality-of-life questionnaire. Patient inclusion for the first multicentre study on coronary anomalies in the Netherlands started in 2020 and will continue for at least 3 years with a minimum of 2 years of follow-up. For patients with a right or left coronary artery originating from the pulmonary artery and coronary arteriovenous fistulas a registry is maintained. Results: Primary outcomes are: (cardiac) death, myocardial ischaemia attributable to the ACAOS, re-intervention after surgery and intervention after initially conservative treatment. The influence of work-up examinations on treatment choice is also evaluated. Conclusions: Structural evidence for the appropriate management of patients with coronary anomalies, especially (interarterial) ACAOS, is lacking. By means of a structured care pathway in a multicentre setting, we aim to provide an evidence-based strategy for the diagnostic evaluation and treatment of this patient group.",

keywords = "Anomalous coronary artery from the opposite sinus of Valsalva, Anomalous coronary artery from the pulmonary artery, Coronary anomalies, Coronary arteriovenous fistula, Multicentre study",

author = "Koppel, {C. J.} and Driesen, {B. W.} and {de Winter}, {R. J.} and {van den Bosch}, {A. E.} and {van Kimmenade}, R. and Wagenaar, {L. J.} and Jukema, {J. W.} and Hazekamp, {M. G.} and {van der Kley}, F. and Jongbloed, {M. R. M.} and P. Ki{\`e}s and Egorova, {A. D.} and Verheijen, {D. B. H.} and P. Damman and Schoof, {P. H.} and J. Wilschut and M. Stoel and Speekenbrink, {R. G. H.} and M. Voskuil and Vliegen, {H. W.}",

note = "Funding Information: P. Damman reports grants and personal fees from Philips, as well as grants from Abbott and AstraZeneca, outside the scope of the submitted work. C.J. Koppel, B.W. Driesen, R.J. de Winter, A.E. van den Bosch, R. van Kimmenade, L.J. Wagenaar, J.W. Jukema, M.G. Hazekamp, F. van der Kley, M.R.M. Jongbloed, P. Ki{\`e}s, A.D. Egorova, D.B.H. Verheijen, P.H. Schoof, J. Wilschut, M. Stoel, R.G.H. Speekenbrink, M. Voskuil and H.W. Vliegen declare that they have no competing interests. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = jun,

day = "1",

doi = "https://doi.org/10.1007/s12471-021-01556-9",

language = "English",

volume = "29",

pages = "311--317",

journal = "Netherlands heart journal",

issn = "1568-5888",

publisher = "Bohn Stafleu van Loghum",

number = "6",

}

Koppel, CJ, Driesen, BW, de Winter, RJ, van den Bosch, AE, van Kimmenade, R, Wagenaar, LJ, Jukema, JW, Hazekamp, MG, van der Kley, F, Jongbloed, MRM, Kiès, P, Egorova, AD, Verheijen, DBH, Damman, P, Schoof, PH, Wilschut, J, Stoel, M, Speekenbrink, RGH, Voskuil, M & Vliegen, HW 2021, 'The first multicentre study on coronary anomalies in the Netherlands: MuSCAT', Netherlands heart journal, vol. 29, no. 6, pp. 311-317. https://doi.org/10.1007/s12471-021-01556-9

TY - JOUR

T1 - The first multicentre study on coronary anomalies in the Netherlands: MuSCAT

AU - Koppel, C. J.

AU - Driesen, B. W.

AU - de Winter, R. J.

AU - van den Bosch, A. E.

AU - van Kimmenade, R.

AU - Wagenaar, L. J.

AU - Jukema, J. W.

AU - Hazekamp, M. G.

AU - van der Kley, F.

AU - Jongbloed, M. R. M.

AU - Kiès, P.

AU - Egorova, A. D.

AU - Verheijen, D. B. H.

AU - Damman, P.

AU - Schoof, P. H.

AU - Wilschut, J.

AU - Stoel, M.

AU - Speekenbrink, R. G. H.

AU - Voskuil, M.

AU - Vliegen, H. W.

N1 - Funding Information: P. Damman reports grants and personal fees from Philips, as well as grants from Abbott and AstraZeneca, outside the scope of the submitted work. C.J. Koppel, B.W. Driesen, R.J. de Winter, A.E. van den Bosch, R. van Kimmenade, L.J. Wagenaar, J.W. Jukema, M.G. Hazekamp, F. van der Kley, M.R.M. Jongbloed, P. Kiès, A.D. Egorova, D.B.H. Verheijen, P.H. Schoof, J. Wilschut, M. Stoel, R.G.H. Speekenbrink, M. Voskuil and H.W. Vliegen declare that they have no competing interests. Publisher Copyright: © 2021, The Author(s).

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Background: Current guidelines on coronary anomalies are primarily based on expert consensus and a limited number of trials. A gold standard for diagnosis and a consensus on the treatment strategy in this patient group are lacking, especially for patients with an anomalous origin of a coronary artery from the opposite sinus of Valsalva (ACAOS) with an interarterial course. Aim: To provide evidence-substantiated recommendations for diagnostic work-up, treatment and follow-up of patients with anomalous coronary arteries. Methods: A clinical care pathway for patients with ACAOS was established by six Dutch centres. Prospectively included patients undergo work-up according to protocol using computed tomography (CT) angiography, ischaemia detection, echocardiography and coronary angiography with intracoronary measurements to assess anatomical and physiological characteristics of the ACAOS. Surgical and functional follow-up results are evaluated by CT angiography, ischaemia detection and a quality-of-life questionnaire. Patient inclusion for the first multicentre study on coronary anomalies in the Netherlands started in 2020 and will continue for at least 3 years with a minimum of 2 years of follow-up. For patients with a right or left coronary artery originating from the pulmonary artery and coronary arteriovenous fistulas a registry is maintained. Results: Primary outcomes are: (cardiac) death, myocardial ischaemia attributable to the ACAOS, re-intervention after surgery and intervention after initially conservative treatment. The influence of work-up examinations on treatment choice is also evaluated. Conclusions: Structural evidence for the appropriate management of patients with coronary anomalies, especially (interarterial) ACAOS, is lacking. By means of a structured care pathway in a multicentre setting, we aim to provide an evidence-based strategy for the diagnostic evaluation and treatment of this patient group.

AB - Background: Current guidelines on coronary anomalies are primarily based on expert consensus and a limited number of trials. A gold standard for diagnosis and a consensus on the treatment strategy in this patient group are lacking, especially for patients with an anomalous origin of a coronary artery from the opposite sinus of Valsalva (ACAOS) with an interarterial course. Aim: To provide evidence-substantiated recommendations for diagnostic work-up, treatment and follow-up of patients with anomalous coronary arteries. Methods: A clinical care pathway for patients with ACAOS was established by six Dutch centres. Prospectively included patients undergo work-up according to protocol using computed tomography (CT) angiography, ischaemia detection, echocardiography and coronary angiography with intracoronary measurements to assess anatomical and physiological characteristics of the ACAOS. Surgical and functional follow-up results are evaluated by CT angiography, ischaemia detection and a quality-of-life questionnaire. Patient inclusion for the first multicentre study on coronary anomalies in the Netherlands started in 2020 and will continue for at least 3 years with a minimum of 2 years of follow-up. For patients with a right or left coronary artery originating from the pulmonary artery and coronary arteriovenous fistulas a registry is maintained. Results: Primary outcomes are: (cardiac) death, myocardial ischaemia attributable to the ACAOS, re-intervention after surgery and intervention after initially conservative treatment. The influence of work-up examinations on treatment choice is also evaluated. Conclusions: Structural evidence for the appropriate management of patients with coronary anomalies, especially (interarterial) ACAOS, is lacking. By means of a structured care pathway in a multicentre setting, we aim to provide an evidence-based strategy for the diagnostic evaluation and treatment of this patient group.

KW - Anomalous coronary artery from the opposite sinus of Valsalva

KW - Anomalous coronary artery from the pulmonary artery

KW - Coronary anomalies

KW - Coronary arteriovenous fistula

KW - Multicentre study

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U2 - https://doi.org/10.1007/s12471-021-01556-9

DO - https://doi.org/10.1007/s12471-021-01556-9

M3 - Article

C2 - 33683666

SN - 1568-5888

VL - 29

SP - 311

EP - 317

JO - Netherlands heart journal

JF - Netherlands heart journal

IS - 6

ER -

The first multicentre study on coronary anomalies in the Netherlands: MuSCAT

Abstract

Keywords

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